Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.
(Modifications: Disulfide bridge between 1 - 11)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1200.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.83 mL||4.17 mL||8.33 mL|
|5 mM||0.17 mL||0.83 mL||1.67 mL|
|10 mM||0.08 mL||0.42 mL||0.83 mL|
|50 mM||0.02 mL||0.08 mL||0.17 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Constandil et al (2012) Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. J.Pain 13 579 PMID: 22560237
Cazorla et al (2010) Cyclotraxin-B, the first highly potent and selective TrkB antagonist, has anxiolytic properties in mice. PLoS One 5 e9777 PMID: 20333308
If you know of a relevant reference for Cyclotraxin B, please let us know.
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Keywords: Cyclotraxin B, supplier, anxiolytic, antagonists, TrkB, receptors, Trk, Receptors, Tocris Bioscience
1 Citation for Cyclotraxin B
Citations are publications that use Tocris products. Selected citations for Cyclotraxin B include:
Zhong et al (2015) BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons. Oncotarget 35 4469 PMID: 25762688
Do you know of a great paper that uses Cyclotraxin B from Tocris? If so please let us know.
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