Cyclotraxin B

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Cat.No. 5062 - Cyclotraxin B | Cys-Asn-Pro-Met-Gly-Tyr-Thr-Lys-Glu-Gly-Cys | CAS No. 1203586-72-4
Description: TrkB receptor antagonist
Datasheet
Citations (1)
Literature

Biological Activity

Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.

Technical Data

M. Wt 1200.36
Formula C48H73N13O17S3
Sequence CNPMGYTKEGC

(Modifications: Disulfide bridge between 1 - 11)

Storage Store at -20°C
CAS Number 1203586-72-4
PubChem ID 90489002
InChI Key JLBMMJHZUYBFGX-ZHTCEXBHSA-N
Smiles [H]N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1200.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.83 mL 4.17 mL 8.33 mL
5 mM 0.17 mL 0.83 mL 1.67 mL
10 mM 0.08 mL 0.42 mL 0.83 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Constandil et al (2012) Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. J.Pain 13 579 PMID: 22560237

Cazorla et al (2010) Cyclotraxin-B, the first highly potent and selective TrkB antagonist, has anxiolytic properties in mice. PLoS One 5 e9777 PMID: 20333308


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Keywords: Cyclotraxin B, supplier, anxiolytic, antagonists, TrkB, receptors, Trk, Receptors, Tocris Bioscience

1 Citation for Cyclotraxin B

Citations are publications that use Tocris products. Selected citations for Cyclotraxin B include:

Zhong et al (2015) BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons. Oncotarget 35 4469 PMID: 25762688


Do you know of a great paper that uses Cyclotraxin B from Tocris? If so please let us know.

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Literature in this Area

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Pathways for Cyclotraxin B

Protocols

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