Cyclotraxin B

Pricing Availability   Qty
Description: TrkB receptor antagonist
Purity: ≥95% (HPLC)
Citations (2)
Literature (3)

Biological Activity for Cyclotraxin B

Cyclotraxin B is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.

Technical Data for Cyclotraxin B

M. Wt 1200.36
Formula C48H73N13O17S3

(Modification: Disulfide bridge: 1-11)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1203586-72-4
PubChem ID 90489002
Smiles [H]N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cyclotraxin B

Solubility Soluble to 2 mg/ml in water

Product Datasheets for Cyclotraxin B

Certificate of Analysis / Product Datasheet
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References for Cyclotraxin B

References are publications that support the biological activity of the product.

Constandil et al (2012) Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. J.Pain 13 579 PMID: 22560237

Cazorla et al (2010) Cyclotraxin-B, the first highly potent and selective TrkB antagonist, has anxiolytic properties in mice. PLoS One 5 e9777 PMID: 20333308

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Keywords: Cyclotraxin B, Cyclotraxin B supplier, anxiolytic, antagonists, TrkB, receptors, Trk, Receptors, 5062, Tocris Bioscience

2 Citations for Cyclotraxin B

Citations are publications that use Tocris products. Selected citations for Cyclotraxin B include:

Merk et al (2018) Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma. Dev Cell 44 709 PMID: 29551561

Zhong et al (2015) BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain DA neurons. Oncotarget 35 4469 PMID: 25762688

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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