HIOC

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Cat.No. 5961 - HIOC | C16H19N3O3 | CAS No. 314054-36-9
Description: Selective TrkB receptor agonist; neuroprotectant
Chemical Name: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant.

Technical Data

M. Wt 301.34
Formula C16H19N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 314054-36-9
PubChem ID 5012758
InChI Key ZIMKJLALTRLXJO-UHFFFAOYSA-N
Smiles OC1=CC=C2NC=C(C2=C1)CCNC(C3CCCNC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 301.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.32 mL 16.59 mL 33.19 mL
5 mM 0.66 mL 3.32 mL 6.64 mL
10 mM 0.33 mL 1.66 mL 3.32 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Setterholm et al (2015) Gram-scale, chemoselective synthesis of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide (HIOC) Tetrahedron Lett. 56 3413 PMID: 26028783

Shen et al (2012) N-acetyl serotonin derivatives as potent neuroprotectants for retinas Proc.Natl.Acad.Sci.USA 109 3540 PMID: 22331903


If you know of a relevant reference for HIOC, please let us know.

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Keywords: Selective TrkB receptor agonists agonism excitotoxicity retinal degeneration blood brain barrier BBB neuroprotectant Trk Receptors

Citations for HIOC

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Literature in this Area

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Pathways for HIOC

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