7,8-Dihydroxyflavone

Pricing Availability   Qty
Description: TrkB agonist
Alternative Names: 7,8-DHF
Chemical Name: 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations (10)
Reviews
Literature (3)

Biological Activity for 7,8-Dihydroxyflavone

7,8-Dihydroxyflavone is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Exhibits neuroprotective effects in an HD mouse model.

Technical Data for 7,8-Dihydroxyflavone

M. Wt 254.24
Formula C15H10O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 38183-03-8
PubChem ID 1880
InChI Key COCYGNDCWFKTMF-UHFFFAOYSA-N
Smiles O=C2C1=CC=C(O)C(O)=C1OC(C3=CC=CC=C3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 7,8-Dihydroxyflavone

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.42 100
2eq. NaOH 25.42 100

Preparing Stock Solutions for 7,8-Dihydroxyflavone

The following data is based on the product molecular weight 254.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.67 mL 39.33 mL
5 mM 0.79 mL 3.93 mL 7.87 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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Product Datasheets for 7,8-Dihydroxyflavone

Certificate of Analysis / Product Datasheet
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References for 7,8-Dihydroxyflavone

References are publications that support the biological activity of the product.

Jang et al (2010) A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc.Natl.Acad.Sci.USA 107 268

Andero et al (2012) 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilzation stress in rats. Hippocampus 22 399 PMID: 21136519

Jiang et al (2013) Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. Hum.Mol.Genet. 22 2462 PMID: 23446639


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View Related Products by Product Action

View all Trk Receptor Agonists

Keywords: 7,8-Dihydroxyflavone, 7,8-Dihydroxyflavone supplier, agonists, TrkB, Neurotrophin, Receptors, Tyrosine, Kinases, RTKs, 7,8-DHF, Trk, 3826, Tocris Bioscience

10 Citations for 7,8-Dihydroxyflavone

Citations are publications that use Tocris products. Selected citations for 7,8-Dihydroxyflavone include:

Meltser et al (2014) TrkB-mediated protection against circadian sensitivity to noise trauma in the murine cochlea. Curr Biol 24 658 PMID: 24583017

Al-Qudah et al (2014) Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C. Am J Physiol Gastrointest Liver Physiol 306 G328 PMID: 24356881

Chitranshi et al (2015) Exploring the Molecular Interactions of 7,8-Dihydroxyflavone and Its Derivatives with TrkB and VEGFR2 Proteins. Purinergic Signal 16 21087 PMID: 26404256

Greising et al (2017) Chronic TrkB agonist treatment in old age does not mitigate diaphragm neuromuscular dysfunction. Physiol Rep 5 PMID: 28082429


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Reviews for 7,8-Dihydroxyflavone

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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