7,8-Dihydroxyflavone

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Cat.No. 3826 - 7,8-Dihydroxyflavone | C15H10O4 | CAS No. 38183-03-8
Description: TrkB agonist
Alternative Names: 7,8-DHF
Chemical Name: 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations (7)
Literature

Biological Activity

Tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Exhibits neuroprotective effects in an HD mouse model.

Technical Data

M. Wt 254.24
Formula C15H10O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 38183-03-8
PubChem ID 1880
InChI Key COCYGNDCWFKTMF-UHFFFAOYSA-N
Smiles O=C2C1=CC=C(O)C(O)=C1OC(C3=CC=CC=C3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.42 100
ethanol 6.36 25
2eq. NaOH 25.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 254.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.67 mL 39.33 mL
5 mM 0.79 mL 3.93 mL 7.87 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Jang et al (2010) A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc.Natl.Acad.Sci.USA 107 268 PMID:

Andero et al (2012) 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilzation stress in rats. Hippocampus 22 399 PMID: 21136519

Jiang et al (2013) Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. Hum.Mol.Genet. 22 2462 PMID: 23446639


If you know of a relevant reference for 7,8-Dihydroxyflavone, please let us know.

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Keywords: agonists TrkB Neurotrophin Receptors Tyrosine Kinases RTKs 7,8-DHF 7,8-DHF Trk Receptors

7 Citations for 7,8-Dihydroxyflavone

Citations are publications that use Tocris products. Selected citations for 7,8-Dihydroxyflavone include:

Shamblott et al (2016) Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas. Cell Communication and Signaling 14 23 PMID: 27659207

Chitranshi et al (2015) Exploring the Molecular Interactions of 7,8-Dihydroxyflavone and Its Derivatives with TrkB and VEGFR2 Proteins. Purinergic Signal 16 21087 PMID: 26404256

Meltser et al (2014) TrkB-mediated protection against circadian sensitivity to noise trauma in the murine cochlea. Curr Biol 24 658 PMID: 24583017

Al-Qudah et al (2014) Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C. Am J Physiol Gastrointest Liver Physiol 306 G328 PMID: 24356881

Choi et al (2013) Effect of 7,8-dihydroxyflavone as an antioxidant on in vitro maturation of oocytes and development of parthenogenetic embryos in pigs. Muscle Nerve 59 450 PMID: 23748647

Abcejo et al (2012) Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle. Int J Mol Sci 7 e44343 PMID: 22952960

Mantilla and Ermilov (2012) The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission. PLoS One 45 274 PMID: 22246885


Do you know of a great paper that uses 7,8-Dihydroxyflavone from Tocris? If so please let us know.

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