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Biological Activity for PF 06273340
PF 06273340 is a potent and selective pan-Trk inhibitor (IC50 values are 1, 2 and 6 nM for Trk C, B and A, respectively). Selective for Trk over a panel of ion channels, receptors and other enzymes. Peripherally restricted. Exhibits efficacy in a rodent model of inflammatory pain. Orally bioavailable.
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for PF 06273340
Technical Data for PF 06273340
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PF 06273340
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PF 06273340
The following data is based on the product molecular weight 479.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.08 mL||10.42 mL||20.84 mL|
|5 mM||0.42 mL||2.08 mL||4.17 mL|
|10 mM||0.21 mL||1.04 mL||2.08 mL|
|50 mM||0.04 mL||0.21 mL||0.42 mL|
References for PF 06273340
References are publications that support the biological activity of the product.
Skerratt et al (2016) The discovery of a potent, selective, and peripherally restricted pan-Trk inhibitor (PF-06273340) for the treatment of pain. J.Med.Chem. 59 10084 PMID: 27766865
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Keywords: PF 06273340, PF 06273340 supplier, PF06273340, Trk, A, B, C, tropomyosin-related, kinase, receptors, neurotrophins, inhibitors, inhibits, peripherally, restricted, potent, selective, Receptors, 6115, Tocris Bioscience
Citations for PF 06273340
Citations are publications that use Tocris products.
Currently there are no citations for PF 06273340. Do you know of a great paper that uses PF 06273340 from Tocris? Please let us know.
Reviews for PF 06273340
Average Rating: 5 (Based on 1 Review.)
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Literature in this Area
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