Demethylasterriquinone B1

Pricing Availability Delivery Time Qty
Cat.No. 1819 - Demethylasterriquinone B1 | C32H30N2O4 | CAS No. 78860-34-1
Description: Selective insulin RTK activator
Alternative Names: DAQ B1, L-783,281, DMAQ-B1
Chemical Name: 2-[2-(1,1-Dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-butenyl)-1H-indol-3-yl]-2,5-cyclohexadiene-1,4-dione
Purity: ≥98% (HPLC)

Biological Activity

Selective insulin receptor (IR) activator (EC50 values are 3 - 6 μM for IRTK and 100 μM for IGF1R and EGFR). Increases IR β subunit tyrosine phosphorylation and activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro, without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site.

Technical Data

M. Wt 506.59
Formula C32H30N2O4
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 78860-34-1
PubChem ID 3013166
Smiles CC(C)=CCC1=C2NC=C(C2=CC=C1)C1=C(O)C(=O)C(C2=C(NC3=CC=CC=C23)C(C)(C)C=C)=C(O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 50.66 100

Preparing Stock Solutions

The following data is based on the product molecular weight 506.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.87 mL 19.74 mL
5 mM 0.39 mL 1.97 mL 3.95 mL
10 mM 0.2 mL 0.99 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the products' biological activity.

Kim et al (2007) Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1. J.Med.Chem. 50 3423 PMID: 17595071

Salituro et al (2001) Discovery of a small molecule insulin receptor activator. Recent Prog.Horm.Res. 56 107 PMID: 11237209

Weber et al (2000) A novel insulin mimetic without a proliferative effect on vascular smooth muscle cells. J.Vasc.Surg. 32 1118 PMID: 11107083

Webster et al (2003) Signaling effects of demethylasterriquinone B1, a selective insulin receptor modulator. Chembiochem 4 379 PMID: 12740809

Wilkie et al (2001) The non-peptidyl fungal metabolite L-783,281 activates TRK neurotrophin receptors. J.Neurochem. 78 1135 PMID: 11553687

If you know of a relevant reference for Demethylasterriquinone B1, please let us know.

View Related Products by Product Action

View all Insulin and Insulin-like Receptor Activators

Keywords: Demethylasterriquinone B1, supplier, Selective, insulin, IRs, RTKs, activators, IGF, Receptors, Insulin-like, Receptor, Tyrosine, Kinases, DemethylasterriquinoneB1, DAQB1, L783281, DAQ, B1, L-783,281, DMAQ-B1, Insulin, and, insulin-like, Receptors, Insulin, and, Insulin-like, Receptors, Trk, Receptors, Insulin, and, insulin-like, Receptors, Tocris Bioscience

Citations for Demethylasterriquinone B1

Citations are publications that use Tocris products.

Currently there are no citations for Demethylasterriquinone B1. Do you know of a great paper that uses Demethylasterriquinone B1 from Tocris? If so please let us know.

Reviews for Demethylasterriquinone B1

There are currently no reviews for this product. Be the first to review Demethylasterriquinone B1 and earn rewards!

Have you used Demethylasterriquinone B1?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area


Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for Demethylasterriquinone B1


Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.