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Biological Activity for Demethylasterriquinone B1
Demethylasterriquinone B1 is a selective insulin receptor (IR) activator (EC50 values are 3 - 6 μM for IRTK and 100 μM for IGF1R and EGFR). Increases IR β subunit tyrosine phosphorylation and activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro, without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site.
Technical Data for Demethylasterriquinone B1
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Demethylasterriquinone B1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Demethylasterriquinone B1
The following data is based on the product molecular weight 506.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.97 mL||9.87 mL||19.74 mL|
|5 mM||0.39 mL||1.97 mL||3.95 mL|
|10 mM||0.2 mL||0.99 mL||1.97 mL|
|50 mM||0.04 mL||0.2 mL||0.39 mL|
Product Datasheets for Demethylasterriquinone B1
References for Demethylasterriquinone B1
References are publications that support the biological activity of the product.
Kim et al (2007) Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the Ins mimic demethylasterriquinone B1. J.Med.Chem. 50 3423 PMID: 17595071
Salituro et al (2001) Discovery of a small molecule Ins receptor activator. Recent Prog.Horm.Res. 56 107 PMID: 11237209
Weber et al (2000) A novel Ins mimetic without a proliferative effect on vascular smooth muscle cells. J.Vasc.Surg. 32 1118 PMID: 11107083
Webster et al (2003) Signaling effects of demethylasterriquinone B1, a selective Ins receptor modulator. Chembiochem 4 379 PMID: 12740809
Wilkie et al (2001) The non-peptidyl fungal metabolite L-783,281 activates TRK neurotrophin receptors. J.Neurochem. 78 1135 PMID: 11553687
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Keywords: Demethylasterriquinone B1, Demethylasterriquinone B1 supplier, Selective, insulin, IRs, RTKs, activators, IGF, Receptors, Insulin-like, Receptor, Tyrosine, Kinases, DemethylasterriquinoneB1, DAQB1, L783281, DAQ, B1, L-783,281, DMAQ-B1, Insulin, and, insulin-like, Trk, 1819, Tocris Bioscience
1 Citation for Demethylasterriquinone B1
Citations are publications that use Tocris products. Selected citations for Demethylasterriquinone B1 include:
Pitt et al (2017) Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers. Mol Biol Cell 28 2623 PMID: 28963439
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Reviews for Demethylasterriquinone B1
Average Rating: 4 (Based on 2 Reviews.)
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.