BDNF (human)
Biological Activity
Member of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors. Enhances the survival, growth and differentiation of neurons. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease.
Technical Data
| M. Wt | 26984 |
| Storage | Store at -20°C |
| CAS Number | 218441-99-7 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 26984. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.04 mL | 0.19 mL | 0.37 mL |
| 5 mM | 0.01 mL | 0.04 mL | 0.07 mL |
| 10 mM | 0 mL | 0.02 mL | 0.04 mL |
| 50 mM | 0 mL | 0 mL | 0.01 mL |
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References
References are publications that support the products' biological activity.
Lipsky and Marini (2007) Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Ann.N.Y.Acad.Sci. 1122 130 PMID: 18077569
Evans and Barker (2008) Neurotrophic factors as a therapeutic target for Parkinson's disease. Expert Opin.Ther.Targets 12 437 PMID: 18348680
Wang et al (2008) The when and where of BDNF and the antidepressant response. Biol.Psychiat. 63 640 PMID:
If you know of a relevant reference for BDNF (human), please let us know.
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Keywords: activators TrkB p75 receptors Neurotrophin Receptors Receptor Tyrosine Kinases RTKs Trk Receptors
3 Citations for BDNF (human)
Citations are publications that use Tocris products. Selected citations for BDNF (human) include:
Zhong et al (2015) BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons. Mol Pain 35 4469 PMID: 25762688
Parsons et al (2014) Bidirectional control of postsynaptic density-95 (PSD-95) clustering by Huntingtin. J Biol Chem 289 3518 PMID: 24347167
Hossaini et al (2010) Nociceptive stimulation induces expression of Arc/Arg3.1 in the spinal cord with a preference for neurons containing enkephalin. Cell Metab 6 43 PMID: 20653942
Do you know of a great paper that uses BDNF (human) from Tocris? If so please let us know.
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