BDNF (human)

Pricing Availability   Qty
Description: Activates TrkB and p75 receptors
Purity: ≥95% (HPLC)
Citations (6)
Reviews (2)
Literature (3)

Biological Activity for BDNF (human)

BDNF (human) is a member of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors. BDNF enhances the survival, growth and differentiation of neurons. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease. In an animal model of Huntington's disease, BDNF administration or overexpression rescues the disease phenotype.

Technical Data for BDNF (human)

M. Wt 26984
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 218441-99-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BDNF (human)

Solubility Soluble in water

Product Datasheets for BDNF (human)

Certificate of Analysis / Product Datasheet
Select another batch:

References for BDNF (human)

References are publications that support the biological activity of the product.

Lipsky and Marini (2007) Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Ann.N.Y.Acad.Sci. 1122 130 PMID: 18077569

Evans and Barker (2008) Neurotrophic factors as a therapeutic target for Parkinson's disease. Expert Opin.Ther.Targets 12 437 PMID: 18348680

Wang et al (2008) The when and where of BDNF and the antidepressant response. Biol.Psychiat. 63 640 PMID: 18329441

Zuccato et al (2005) Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery. Pharmacol.Res. 52 133 PMID: 15967378

If you know of a relevant reference for BDNF (human), please let us know.

View Related Products by Product Action

View all Trk Receptor Agonists

Keywords: BDNF (human), BDNF (human) supplier, activators, TrkB, p75, receptors, Neurotrophin, Receptors, Receptor, Tyrosine, Kinases, RTKs, huntingtons, Trk, Organoids, 2837, Tocris Bioscience

6 Citations for BDNF (human)

Citations are publications that use Tocris products. Selected citations for BDNF (human) include:

Hashimotodani et al (2017) LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance. Neuron 95 928 PMID: 28817805

Li et al (2011) Synergistic activation of DA D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala. PLoS One 6 e26065 PMID: 22022509

Chiara et al (2010) Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum. J Neurosci 30 8127 PMID: 20554863

Hossaini et al (2010) Nociceptive stimulation induces expression of Arc/Arg3.1 in the spinal cord with a preference for neurons containing enkephalin. Cell Metab 6 43 PMID: 20653942

Do you know of a great paper that uses BDNF (human) from Tocris? Please let us know.

Reviews for BDNF (human)

Average Rating: 4.5 (Based on 2 Reviews.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used BDNF (human)?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Smooth muscle activation.
By Mohammad Alqudah on 10/19/2022
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Smooth muscle

Used to activate primary smooth muscle culture at 1 nM.Good results

Increases neurite outgrowth in human neurons.
By Karthik Krishnamurthy on 11/15/2021
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: iPS neurons

Used at a concentration of 10 ng/ml. Increases neurite growth in human iPS neurons. The image shows the labeling of MAP-2 in human iPS neurons treated with BDNF for a week.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Huntington's Disease Poster

Huntington's Disease Poster

Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.