BDNF (human)

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Cat.No. 2837 - BDNF (human) | CAS No. 218441-99-7
Description: Activates TrkB and p75 receptors
Datasheet
Citations (5)
Reviews
Literature

Biological Activity

Member of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors. Enhances the survival, growth and differentiation of neurons. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease.

Technical Data

M. Wt 26984
Storage Store at -20°C
CAS Number 218441-99-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Lipsky and Marini (2007) Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Ann.N.Y.Acad.Sci. 1122 130 PMID: 18077569

Evans and Barker (2008) Neurotrophic factors as a therapeutic target for Parkinson's disease. Expert Opin.Ther.Targets 12 437 PMID: 18348680

Wang et al (2008) The when and where of BDNF and the antidepressant response. Biol.Psychiat. 63 640


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Keywords: BDNF (human), BDNF (human) supplier, activators, TrkB, p75, receptors, Neurotrophin, Receptors, Receptor, Tyrosine, Kinases, RTKs, Trk, 2837, Tocris Bioscience

5 Citations for BDNF (human)

Citations are publications that use Tocris products. Selected citations for BDNF (human) include:

Li et al (2011) Synergistic activation of dopamine D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala. PLoS One 6 e26065 PMID: 22022509

Zhong et al (2015) BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons. Mol Pain 35 4469 PMID: 25762688

Parsons et al (2014) Bidirectional control of postsynaptic density-95 (PSD-95) clustering by Huntingtin. J Biol Chem 289 3518 PMID: 24347167

Hossaini et al (2010) Nociceptive stimulation induces expression of Arc/Arg3.1 in the spinal cord with a preference for neurons containing enkephalin. Cell Metab 6 43 PMID: 20653942

Chiara et al (2010) Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum. J Neurosci 30 8127 PMID: 20554863


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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