LM 22A4

Pricing Availability Delivery Time Qty
Cat.No. 4607 - LM 22A4 | C15H21N3O6 | CAS No. 37988-18-4
Description: Potent TrkB agonist
Chemical Name: N,N',N''Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)

Biological Activity

Potent tropomyosin-related kinase B (TrkB) agonist (IC50 = 47 nM). Induces activation of Trk, Akt and ERK in mouse hippocampus and striatum. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome.

Compound Libraries

LM 22A4 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 339.34
Formula C15H21N3O6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 37988-18-4
PubChem ID 2054170
InChI Key RGWJKANXFYJKHN-UHFFFAOYSA-N
Smiles O=C(NCCO)C1=CC(C(NCCO)=O)=CC(C(NCCO)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.93 100
water 33.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 339.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.73 mL 29.47 mL
5 mM 0.59 mL 2.95 mL 5.89 mL
10 mM 0.29 mL 1.47 mL 2.95 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Massa et al (2010) Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J.Clin.Invest. 120 1774 PMID: 20407211

Schmid et al (2012) A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. J.Neurosci. 32 1803 PMID: 22302819


If you know of a relevant reference for LM 22A4, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Trk Receptor Agonists

Keywords: LM22A4 tropomyosin related kinases B TrkB agonists potent Rett syndrome Trk Receptors

1 Citation for LM 22A4

Citations are publications that use Tocris products. Selected citations for LM 22A4 include:

Al-Qudah et al (2014) Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C. Am J Physiol Gastrointest Liver Physiol 306 G328 PMID: 24356881


Do you know of a great paper that uses LM 22A4 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Pathways for LM 22A4

Protocols

TODO: Add Protocols