Potent tropomyosin-related kinase B (TrkB) agonist (IC50 = 47 nM). Induces activation of Trk, Akt and ERK in mouse hippocampus and striatum. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 339.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.95 mL||14.73 mL||29.47 mL|
|5 mM||0.59 mL||2.95 mL||5.89 mL|
|10 mM||0.29 mL||1.47 mL||2.95 mL|
|50 mM||0.06 mL||0.29 mL||0.59 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Massa et al (2010) Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J.Clin.Invest. 120 1774 PMID: 20407211
Schmid et al (2012) A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. J.Neurosci. 32 1803 PMID: 22302819
If you know of a relevant reference for LM 22A4, please let us know.
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Keywords: LM22A4 tropomyosin related kinases B TrkB agonists potent Rett syndrome Trk Receptors
1 Citation for LM 22A4
Citations are publications that use Tocris products. Selected citations for LM 22A4 include:
Al-Qudah et al (2014) Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C. Am J Physiol Gastrointest Liver Physiol 306 G328 PMID: 24356881
Do you know of a great paper that uses LM 22A4 from Tocris? If so please let us know.