LM 22A4

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Cat.No. 4607 - LM 22A4 | C15H21N3O6 | CAS No. 37988-18-4
Description: Potent TrkB agonist
Chemical Name: N,N',N''Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent tropomyosin-related kinase B (TrkB) agonist. Induces activation of Trk, Akt and ERK in mouse hippocampus and striatum and exhibits neurotrophic activity. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome.

Compound Libraries

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Technical Data

M. Wt 339.34
Formula C15H21N3O6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 37988-18-4
PubChem ID 2054170
InChI Key RGWJKANXFYJKHN-UHFFFAOYSA-N
Smiles O=C(NCCO)C1=CC(C(NCCO)=O)=CC(C(NCCO)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.93 100
water 33.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 339.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.73 mL 29.47 mL
5 mM 0.59 mL 2.95 mL 5.89 mL
10 mM 0.29 mL 1.47 mL 2.95 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Massa et al (2010) Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J.Clin.Invest. 120 1774 PMID: 20407211

Schmid et al (2012) A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. J.Neurosci. 32 1803 PMID: 22302819


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View all Trk Receptor Agonists

Keywords: LM 22A4, LM 22A4 supplier, LM22A4, tropomyosin, related, kinases, B, TrkB, agonists, potent, Rett, syndrome, Trk, Receptors, 4607, Tocris Bioscience

1 Citation for LM 22A4

Citations are publications that use Tocris products. Selected citations for LM 22A4 include:

Al-Qudah et al (2014) Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C. Am J Physiol Gastrointest Liver Physiol 306 G328 PMID: 24356881


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