ANA 12

Pricing Availability Delivery Time Qty
Cat.No. 4781 - ANA 12 | C22H21N3O3S | CAS No. 219766-25-3
Description: TrkB receptor antagonist
Chemical Name: N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]benzo[b]thiophene-2-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

TrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Displays no effect on TrkA and TrkC in an assay of neurite outgrowth. Demonstrates antidepressant properties.

Compound Libraries

ANA 12 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 407.49
Formula C22H21N3O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 219766-25-3
PubChem ID 2799722
InChI Key TUSCYCAIGRVBMD-UHFFFAOYSA-N
Smiles O=C(NC4C(NCCCC4)=O)C1=C(NC(C2=CC3=C(C=CC=C3)S2)=O)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.37 50

Preparing Stock Solutions

The following data is based on the product molecular weight 407.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.27 mL 24.54 mL
5 mM 0.49 mL 2.45 mL 4.91 mL
10 mM 0.25 mL 1.23 mL 2.45 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cazorla et al (2011) Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J.Clin.Invest. 121 1846 PMID: 21505263


If you know of a relevant reference for ANA 12, please let us know.

View Related Products by Product Action

View all Trk Receptor Antagonists

Keywords: ANA12 TrkB receptors antagonists BDNF antidepressants Trk Receptors

2 Citations for ANA 12

Citations are publications that use Tocris products. Selected citations for ANA 12 include:

Shamblott et al (2016) Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2(TRKB) signaling in the adult human exocrine pancreas. Cell Communication and Signaling 14 23 PMID: 27659207

Stepan et al (2015) High-Speed imaging reveals opposing effects of chronic stress and antidepressants on neuronal activity propagation through the hippocampal trisynaptic circuit. Front Neural Circuits 9 70 PMID: 26594153


Do you know of a great paper that uses ANA 12 from Tocris? If so please let us know.

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Reviews

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Literature in this Area

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Pathways for ANA 12

Protocols

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