Poly(ADP-ribose) Polymerase

Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
0788 3-Aminobenzamide
PARP inhibitor
6060 AZD 2461
Potent PARP inhibitor; orally bioavailable
5817 BSI 201
PARP-1 inhibitor
3734 BYK 204165
Selective PARP-1 inhibitor
3735 BYK 49187
PARP-1 and PARP-2 inhibitor
2496 DR 2313
PARP-1 and PARP-2 inhibitor
4140 EB 47
Potent PARP-1 inhibitor
2192 4-HQN
PARP inhibitor
5054 ME 0328
Selective PARP-3 inhibitor
4106 Nicotinamide
PARP-1 inhibitor
1401 NU 1025
Potent PARP inhibitor
6344 OUL 35
Selective PARP-10 inhibitor
6461 PARPi-FL
Potent fluorescent PARP inhibitor; cell permeable
3255 PJ 34 hydrochloride
Potent PARP inhibitor
6230 Rucaparib camsylate
PARP inhibitor
3736 UPF 1069
PARP-2 inhibitor

Related Targets

Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein, and also polymerizes ADP-ribose to form long/branched chain polymers. Tankyrase proteins also display PARP activity.

PARP-1, one of 5 confirmed PARPs, is the most abundant and highly expressed PARP enzyme. PARP-1 detects and relocates to single strand breaks or nicks in chromosomal DNA. PARP-1 is thought to play an important role in the initiation of the DNA repair pathway, although high levels of activation are also associated with increased apoptosis in response to genotoxic stress. In addition, PARP-1 may also operate downstream of the Raf-MEK-ERK pathway through direct interaction with ERK2 in the nucleus. PARP inhibitors are being developed for use in a number of pathologies including cancer, diabetes, stroke and cardiovascular disease.

Tankyrases 1 and 2 (TNKS1/PARP5A and TNKS2/PARP5B/PARP5C) are proteins with poly(ADP-ribose) polymerase activity. Human tankyrases post-translationally modify multiple proteins involved in processes including maintenance of telomere length, sister telomere association, insulin responsiveness, spindle assembly and trafficking of GLUT4-containing vesicles. Recently tankyrases have been shown to be involved in the Wnt signaling pathway. Tankyrases bind directly to axin, a member of the 'destruction complex' involved in β-catenin degradation. Inhibition of tankyrase stabilizes axin, increases the activity of the destruction complex and promotes degradation of β-catenin. Tankyrases are therefore an attractive target for cancer therapy.

Poly-ADP-ribosylation of histone proteins is also emerging as an important epigenetic regulatory mechanism.

External sources of pharmacological information for Poly(ADP-ribose) Polymerase :

    Literature for Poly(ADP-ribose) Polymerase

    Tocris offers the following scientific literature for Poly(ADP-ribose) Polymerase to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


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    Poly (ADP-ribose) polymerase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    PARP1 Human PARP1 NM_001618 P09874
    Mouse Parp1 NM_007415 P11103
    Rat Parp1 NM_013063 P27008
    PARP2 Human PARP2 NM_005484 Q9UGN5
    Mouse Parp2 NM_009632 O88554
    Rat Parp2 NM_001106030 NP_001099500
    PARP3 Human PARP3 NM_001003935 Q9Y6F1
    Mouse Parp3 NM_145619 NP_663594
    Rat Parp3 NM_001008328 Q5U2U3
    PARP4 Human PARP4 NM_006437 Q9UKK3
    Mouse Parp4 AK164513 Q6A0B1
    PARP5A (TNKS1) Human TNKS NM_003747 O95271
    Mouse Tnks NM_175091 NP_780300
    PARP5B/5C (TNKS2) Human TNKS2 NM_025235 Q9H2K2
    Mouse Tnks2 NM_001163635 NP_001157107
    PARP6 Human PARP6 NM_020214 Q2NL67
    Mouse Parp6 NM_029922 Q6P6P7
    PARP8 Human PARP8 NM_024615 Q8N3A8
    Mouse Parp8 NM_001081009 Q3UD82
    PARP9 Human PARP9 NM_031458 Q8IXQ6
    Mouse Parp9 NM_030253 Q8CAS9
    PARP10 Human PARP10 NM_032789 Q53GL7
    Mouse Parp10 AK035309 Q3TLV7
    PARP11 Human PARP11 NM_020367 Q9NR21
    Mouse Parp11 NM_181402 Q8CFF0
    PARP12 Human PARP12 NM_022750 Q9H0J9
    Mouse PARP12 NM_172893 Q8BZ20s
    PARP14 Human PARP14 NM_017554 Q460N5
    Mouse Parp14 NM_001039530 Q2EMV9
    PARP15 Human PARP15 NM_152615 Q460N3
    PARP16 Human PARP16 NM_017851 Q8N5Y8
    Mouse Parp16 NM_177460 NM_177460
    Rat Parp16 NM_173331 Q5U2Q4