PJ 34 hydrochloride

Pricing Availability   Qty
Description: Potent PARP inhibitor
Chemical Name: N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamide hydrochloride
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for PJ 34 hydrochloride

PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM). ~1000-fold more potent than 3-Aminobenzamide (Cat. No. 0788). Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo. Displays protective effects against cisplatin-induced kidney injury. Also displays activity at Pim-1 and Pim-2 kinases at higher concentrations (IC50 values are 3.7 and 16 μM respectively).

Compound Libraries for PJ 34 hydrochloride

PJ 34 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for PJ 34 hydrochloride

M. Wt 331.8
Formula C17H17N3O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 344458-15-7
PubChem ID 16760621
Smiles Cl.CN(C)CC(=O)NC1=CC2=C(NC(=O)C3=CC=CC=C23)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PJ 34 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 33.18 100
DMSO 33.18 100

Preparing Stock Solutions for PJ 34 hydrochloride

The following data is based on the product molecular weight 331.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.07 mL 30.14 mL
5 mM 0.6 mL 3.01 mL 6.03 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for PJ 34 hydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for PJ 34 hydrochloride

References are publications that support the biological activity of the product.

Abdelkarim et al (2001) Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. Int.J.Mol.Med. 7 255 PMID: 11179503

Gambi et al (2008) Poly(ADPR)polymerase inhibition and apoptosis induction in cDDP-treated human carcinoma cell lines. Biochem.Pharmacol. 75 2356 PMID: 18468580

Kim et al (2012) Poly(ADP-ribose) polymerase 1 activation is required for cisp. nephrotoxicity. Kidney Int. 82 193 PMID: 22437413

Antolin et al (2012) Identification of Pim kinases as novel targets for PJ34 with confounding effects in PARP biology. ACS Chem.Biol. 7 1962 PMID: 23025350

If you know of a relevant reference for PJ 34 hydrochloride, please let us know.

View Related Products by Product Action

View all Poly(ADP-Ribose) Polymerase Inhibitors

Keywords: PJ 34 hydrochloride, PJ 34 hydrochloride supplier, Potent, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerases, PJ34, hydrochloride, Poly(ADP-ribose), Polymerase, 3255, Tocris Bioscience

1 Citation for PJ 34 hydrochloride

Citations are publications that use Tocris products. Selected citations for PJ 34 hydrochloride include:

Kirby et al (2012) Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939. Acta Crystallogr Sect F Struct Biol Cryst Commun 68 115 PMID: 22297980

Do you know of a great paper that uses PJ 34 hydrochloride from Tocris? Please let us know.

Reviews for PJ 34 hydrochloride

There are currently no reviews for this product. Be the first to review PJ 34 hydrochloride and earn rewards!

Have you used PJ 34 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.