Post-translational Modifications

Post-translational modifications are chemical changes to a protein that occur after translation widening the range of functions of the final protein. Many modifications occur in the RER (rough endoplasmic reticulum). There are five types of post-translational modification.

Literature (1)

Post-Translational Modification Inhibitors

Cat. No. Product Name / Activity
3084 Anacardic acid
Inhibits SUMOylation; also inhibits histone acetyltransferase
1744 Bay 11-7821
E2 ubiquitin (Ub) conjugating enzymes inhibitor
4200 C 646
Selective p300/CBP inhibitor
5646 EML 425
Reversible and non-competitive p300/CBP inhibitor
2430 GGTI 298
Geranylgeranyltransferase I (GGTase I) inhibitor
6326 Ginkgolic Acid
Inhibitor of SUMOylation
6265 Lonafarnib
Potent farnesyl transferase inhibitor
4993 NSC 624206
Ubiquitin-activating enzyme (E1) inhibitor
4858 NSC 697923
Selective UBE2N inhibitor
4903 NU 9056
Inhibitor of KAT5 (Tip60) histone acetyltransferase
2978 PYR 41
Ubiquitin-activating enzyme (E1) inhibitor
6410 Tipifarnib
Potent farnesyltransferase inhibitor; orally bioavailable


Cat. No. Product Name / Activity
7479 Ac4ManNAz
Azide-containing monosaccharide building block; used as glycoprotein, glycolipid and glycoRNA probe
7553 Ac4ManNDAz
Photo-crosslinking probe for studying glycoproteins and glycolipids
7234 Nitazoxanide
Stabilizes peptidyl arginine deiminase 2 (PAD2); inhibits Wnt signaling; broad spectrum anti-infective

Post-translational modifications are chemical changes to a protein that occur after translation. They widen the range of functions of the final protein. Many of these protein modifications occur in the rough endoplasmic reticulum (RER). There are five types of post-translational modifications:

  1. Formation of disulfide bridges
  2. Proper folding
  3. Addition and processing of carbohydrates
  4. Specific proteolytic cleavage
  5. Assembly into multimeric proteins

Examples of specific post-translational modifications include phosphorylation, sumolyation, ubiquitination, acetylation, methylation, glycosylation, hydroxylation, oxidation and deamination (conversion of arginine to citrulline). As all proteins begin with methionine, many have this first amino acid cleaved off during post-translational modification. This process occurs predominantly in the ER, Golgi and secretory vesicles.

Literature for Post-translational Modifications

Tocris offers the following scientific literature for Post-translational Modifications to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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