Post-translational Modifications

Post-translational modifications are chemical changes to a protein that occur after translation widening the range of functions of the final protein. Many modifications occur in the RER (rough endoplasmic reticulum). There are five types of post-translational modification.

Products
Background
Literature

Inhibitors

Cat No Product Name / Activity
1744 Bay 11-7821
E2 ubiquitin (Ub) conjugating enzymes inhibitor
4200 C 646
Selective p300/CBP inhibitor
4503 CC 0651
Allosteric inhibitor of hCdc34
3416 Tris DBA
N-myristoyltransferase-1 inhibitor; antiproliferative
5646 EML 425
Reversible and non-competitive p300/CBP inhibitor
2407 FTI 277
Prodrug form of FTI 276 (Cat. No. 2406)
2430 GGTI 298
Geranylgeranyltransferase I (GGTase I) inhibitor
2637 Gliotoxin
Farnesyltransferase and geranylgeranyltransferase I inhibitor
5045 L002
p300 inhibitor
4294 LB 42708
Selective farnesyltransferase (FTase) inhibitor
6265 Lonafarnib
Potent farnesyl transferase inhibitor
5103 Lys-CoA
Selective p300 inhibitor
4993 NSC 624206
Ubiquitin-activating enzyme (E1) inhibitor
4858 NSC 697923
Selective UBE2N inhibitor
4903 NU 9056
Inhibitor of KAT5 (Tip60) histone acetyltransferase
2978 PYR 41
Ubiquitin-activating enzyme (E1) inhibitor
4994 PYZD 4409
Ubiquitin-activating enzyme (E1) inhibitor
5482 TDFA
PAD4 inhibitor

Post-translational modifications are chemical changes to a protein that occur after translation. They widen the range of functions of the final protein. Many of these protein modifications occur in the rough endoplasmic reticulum (RER). There are five types of post-translational modifications:

  1. Formation of disulfide bridges
  2. Proper folding
  3. Addition and processing of carbohydrates
  4. Specific proteolytic cleavage
  5. Assembly into multimeric proteins

Examples of specific post-translational modifications include phosphorylation, sumolyation, ubiquitination, acetylation, methylation, glycosylation, hydroxylation, oxidation and deamination (conversion of arginine to citrulline). As all proteins begin with methionine, many have this first amino acid cleaved off during post-translational modification. This process occurs predominantly in the ER, Golgi and secretory vesicles.

Literature for Post-translational Modifications

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis