Nicotinamide

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Cat.No. 4106 - Nicotinamide | C6H6N2O | CAS No. 98-92-0
Description: PARP-1 inhibitor
Chemical Name: Pyridine-3-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Anti-inflammatory agent. Inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. NAD+ precursor. Promotes differentiation of mesenchymal stem cells to insulin producing cells when used in combination with growth factors and high glucose concentration.

Compound Libraries

Nicotinamide is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 122.12
Formula C6H6N2O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 98-92-0
PubChem ID 936
InChI Key DFPAKSUCGFBDDF-UHFFFAOYSA-N
Smiles O=C(C1=CC=CN=C1)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.21 100
ethanol 12.21 100

Preparing Stock Solutions

The following data is based on the product molecular weight 122.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 8.19 mL 40.94 mL 81.89 mL
5 mM 1.64 mL 8.19 mL 16.38 mL
10 mM 0.82 mL 4.09 mL 8.19 mL
50 mM 0.16 mL 0.82 mL 1.64 mL

Molarity Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Suzuki et al (2010) Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake. Life.Sci. 86 676 PMID: 20188745

Cimadamore et al (2009) Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death. Stem Cells. 27 1772 PMID: 19544437

Czubak et al (2014) A modified method of Ins producing cells' generation from bone marrow-derived mesenchymal stem cells. J.Diabetes Res. 2014 628591 PMID: 25405207


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Keywords: Nicotinamide, Nicotinamide supplier, Nicotinamide, inhibits, poly(ADP-ribose), polymerase-1, PARP-1, inhibitors, anti-inflammatory, organoids, Poly(ADP-ribose), Polymerase, Mesenchymal, Stem, Cells, 4106, Tocris Bioscience

Citations for Nicotinamide

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