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Fluorescent potent PARP inhibitor (IC50 = 12 nM). Composed of a PARP inhibitor conjugated to BDY FL, SE (Cat. No. 5465). Colocalizes with PARP immunostaining in multiple cancer cell lines in vivo and accumulates in tumor cells and tumor associated macrophages. Enables high temporal and subcellular spatial resolution of drug distribution. Emission max = 525 nm. Cell permeable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 640.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||15.61 mL||78.07 mL||156.14 mL|
|0.5 mM||3.12 mL||15.61 mL||31.23 mL|
|1 mM||1.56 mL||7.81 mL||15.61 mL|
|5 mM||0.31 mL||1.56 mL||3.12 mL|
References are publications that support the biological activity of the product.
Thurber et al (2013) Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat.Commun. 4 1504 PMID: 23422672
Thurber et al (2014) Effect of small-molecule modification on single-cell pharmacokinetics of PARP inhibitors. Mol.Cancer Ther. 13 986 PMID: 24552776
Dubach et al (2017) Quantitating drug-target engagement in single cells in vitro and in vivo. Nat.Chem.Biol. 13 168 PMID: 27918558
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Keywords: PARPi-FL, PARPi-FL supplier, fluorescent, PARP, inhibitors, potent, inhibits, poly, ADP, ribose, polymerase, post, translational, modification, Poly(ADP-ribose), Polymerase, Fluorescent, Ligands, 6461, Tocris Bioscience
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.