You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for PARPi-FL
PARPi-FL is a fluorescent potent PARP inhibitor (IC50 = 12 nM). Composed of a PARP inhibitor conjugated to BDY FL, SE (Cat. No. 5465). Colocalizes with PARP immunostaining in multiple cancer cell lines in vivo and accumulates in tumor cells and tumor associated macrophages. Enables high temporal and subcellular spatial resolution of drug distribution. Emission max = 525 nm. Cell permeable.
Optical Data for PARPi-FL
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.Spectral Viewer
Technical Data for PARPi-FL
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PARPi-FL
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PARPi-FL
The following data is based on the product molecular weight 640.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||15.61 mL||78.07 mL||156.14 mL|
|0.5 mM||3.12 mL||15.61 mL||31.23 mL|
|1 mM||1.56 mL||7.81 mL||15.61 mL|
|5 mM||0.31 mL||1.56 mL||3.12 mL|
References for PARPi-FL
References are publications that support the biological activity of the product.
Thurber et al (2013) Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat.Commun. 4 1504 PMID: 23422672
Thurber et al (2014) Effect of small-molecule modification on single-cell pharmacokinetics of PARP inhibitors. Mol.Cancer Ther. 13 986 PMID: 24552776
Dubach et al (2017) Quantitating drug-target engagement in single cells in vitro and in vivo. Nat.Chem.Biol. 13 168 PMID: 27918558
If you know of a relevant reference for PARPi-FL, please let us know.
View Related Products by Target
Keywords: PARPi-FL, PARPi-FL supplier, fluorescent, PARP, inhibitors, potent, inhibits, poly, ADP, ribose, polymerase, post, translational, modification, TR, -FRET, acceptor, Poly(ADP-ribose), Polymerase, Enzyme, Probes, and, Substrates, TR-FRET, FP, Assay, Reagents, 6461, Tocris Bioscience
Citations for PARPi-FL
Citations are publications that use Tocris products.
Currently there are no citations for PARPi-FL. Do you know of a great paper that uses PARPi-FL from Tocris? Please let us know.
Reviews for PARPi-FL
There are currently no reviews for this product. Be the first to review PARPi-FL and earn rewards!
Have you used PARPi-FL?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Fluorescent Dyes and Probes Research Product Guide
This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:
- Fluorescent Dyes, including dyes for flow cytometry
- Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
- Tissue Clearing Kits and Reagents
- Aptamer-based RNA Imaging Reagents
- Fluorescent Probes for Imaging Bacteria
- TSA VividTM Fluorophore Kits
- TSA Reagents for Enhancing IHC, ICC & FISH Signals