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Description: PARP inhibitor; photoaffinity probe
Chemical Name: 3-(3-Butyn-1-yl)-N-[5-cyano-6-[4-[3-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]benzoyl]-1-piperazinyl]-3-pyridinyl]-3H-diazirine-3-propanamide
Purity: ≥95% (HPLC)
Literature (4)

Biological Activity for PARPYnD

PARPYnD is a potent photoaffinity probe for poly(ADP-ribose) polymerase (PARP) (IC50 values for PARP2, PARP1 and PARP6 are 6, 38 and 230 nM, respectively). PARPYnD labels PARP1 and PARP2 in the cell when an N3 functionalized fluorescent probe is attached and can inhibit isolated PARP6.

Technical Data for PARPYnD

M. Wt 613.68
Formula C34H31N9O3
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2561483-27-8
Smiles O=C(NC1=CN=C(C(C#N)=C1)N2CCN(C(C3=CC(CC4=NNC(C5=CC=CC=C45)=O)=CC=C3)=O)CC2)CCC6(N=N6)CCC#C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PARPYnD

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 61.37 100

Preparing Stock Solutions for PARPYnD

The following data is based on the product molecular weight 613.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.63 mL 8.15 mL 16.3 mL
5 mM 0.33 mL 1.63 mL 3.26 mL
10 mM 0.16 mL 0.81 mL 1.63 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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References for PARPYnD

References are publications that support the biological activity of the product.

Howard et al (2020) Structure-guided design and in-cell target profiling of a cell-active target engagement probe for PARP inhibitors. ACS Chem.Biol. 15 325 PMID: 32017532

If you know of a relevant reference for PARPYnD, please let us know.

View Related Products by Product Action

View all Poly(ADP-Ribose) Polymerase Inhibitors

Keywords: PARPYnD, PARPYnD supplier, potent, PARP1, PARP2, PARP6, enzymes, inhibitors, photoaffinity, probes, polymerase, Poly(ADP-ribose), Polymerase, 7410, Tocris Bioscience

Citations for PARPYnD

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Currently there are no citations for PARPYnD. Do you know of a great paper that uses PARPYnD from Tocris? Please let us know.

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Literature in this Area

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