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Biological Activity for PARPYnD
PARPYnD is a potent photoaffinity probe for poly(ADP-ribose) polymerase (PARP) (IC50 values for PARP2, PARP1 and PARP6 are 6, 38 and 230 nM, respectively). PARPYnD labels PARP1 and PARP2 in the cell when an N3 functionalized fluorescent probe is attached and can inhibit isolated PARP6.
Technical Data for PARPYnD
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PARPYnD
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PARPYnD
The following data is based on the product molecular weight 613.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.63 mL||8.15 mL||16.3 mL|
|5 mM||0.33 mL||1.63 mL||3.26 mL|
|10 mM||0.16 mL||0.81 mL||1.63 mL|
|50 mM||0.03 mL||0.16 mL||0.33 mL|
References for PARPYnD
References are publications that support the biological activity of the product.
Howard et al (2020) Structure-guided design and in-cell target profiling of a cell-active target engagement probe for PARP inhibitors. ACS Chem.Biol. 15 325 PMID: 32017532
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Keywords: PARPYnD, PARPYnD supplier, potent, PARP1, PARP2, PARP6, enzymes, inhibitors, photoaffinity, probes, polymerase, Poly(ADP-ribose), Polymerase, 7410, Tocris Bioscience
Citations for PARPYnD
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Literature in this Area
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Cell Cycle and DNA Damage Research Product Guide
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.