You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
PARP inhibitor (IC50 = 120 μM). Displays cytoprotective effects in various disease models: decreases ROS levels, lipid peroxidation and single-strand DNA breaks in isolated reperfused rat hearts; improves mitochondrial function and protects against neuronal cell death in a mouse model of familial dysautonomia. Also activates HSP70 in rodent skeletal muscle, increasing oxidative capacity and improving insulin sensitivity.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||7.03||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 351.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.85 mL||14.23 mL||28.47 mL|
|5 mM||0.57 mL||2.85 mL||5.69 mL|
|10 mM||0.28 mL||1.42 mL||2.85 mL|
|50 mM||0.06 mL||0.28 mL||0.57 mL|
References are publications that support the biological activity of the product.
Szabados et al (2000) BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase. Biochem.Pharmacol. 59 937 PMID: 10692558
Racz et al (2002) BGP-15 - a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin without compromising its antitumor activity. Biochem.Pharmacol. 63 1099 PMID: 11931842
Henstridge et al (2014) Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance. Diabetes. 63 1881 PMID: 24430435
Ohlen et al (2017) BGP-15 prevents the death of neurons in a mouse model of familial dysautonomia. Proc.Natl.Acad.Sci.U.S.A 114 5035 PMID: 28439028
Chung et al (2008) HSP72 protects against obesity-induced insulin resistance. Proc.Natl.Acad.Sci.U.S.A 105 1739 PMID: 18223156
If you know of a relevant reference for BGP 15, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: BGP 15, BGP 15 supplier, BGP15, cytoprotectant, chemoprotectant, PARP, inhibitors, inhibits, Hsp70, protein, 1, Hsp72, activators, activates, Poly(ADP-ribose), Polymerase, 6703, Tocris Bioscience
Citations for BGP 15
Citations are publications that use Tocris products.
Currently there are no citations for BGP 15. Do you know of a great paper that uses BGP 15 from Tocris? Please let us know.
Reviews for BGP 15
There are currently no reviews for this product. Be the first to review BGP 15 and earn rewards!
Have you used BGP 15?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.