BGP 15

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Cat.No. 6703 - BGP 15 | C14H22N4O2.2HCl | CAS No. 66611-37-8
Description: PARP inhibitor; cytoprotectant
Chemical Name: N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

PARP inhibitor (IC50 = 120 μM). Displays cytoprotective effects in various disease models: decreases ROS levels, lipid peroxidation and single-strand DNA breaks in isolated reperfused rat hearts; improves mitochondrial function and protects against neuronal cell death in a mouse model of familial dysautonomia. Also activates HSP70 in rodent skeletal muscle, increasing oxidative capacity and improving insulin sensitivity.

Technical Data

M. Wt 351.27
Formula C14H22N4O2.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 66611-37-8
PubChem ID 70701185
InChI Key ISGGVCWFTPTHIX-UHFFFAOYSA-N
Smiles OC(CN1CCCCC1)CONC(C2=CN=CC=C2)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 35.13 100
DMSO 7.03 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 351.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.23 mL 28.47 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References

References are publications that support the biological activity of the product.

Szabados et al (2000) BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase. Biochem.Pharmacol. 59 937 PMID: 10692558

Racz et al (2002) BGP-15 - a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin without compromising its antitumor activity. Biochem.Pharmacol. 63 1099 PMID: 11931842

Henstridge et al (2014) Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance. Diabetes. 63 1881 PMID: 24430435

Ohlen et al (2017) BGP-15 prevents the death of neurons in a mouse model of familial dysautonomia. Proc.Natl.Acad.Sci.U.S.A 114 5035 PMID: 28439028

Chung et al (2008) HSP72 protects against obesity-induced insulin resistance. Proc.Natl.Acad.Sci.U.S.A 105 1739 PMID: 18223156


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Citations for BGP 15

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Literature in this Area

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