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Biological Activity for OUL 35
OUL 35 is a selective PARP-10 (also known as ADP-ribosyltransferase Diptheria Toxin-like 10, ARTD10) inhibitor (IC50 = 0.329 μM). Displays selectivity for PARP-10 over a panel of PARP family members. Rescues HeLa cells from PARP-10-induced cell death. Sensitizes cancer cells to hydroxyurea-induced genotoxic stress.
Compound Libraries for OUL 35
Technical Data for OUL 35
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for OUL 35
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for OUL 35
The following data is based on the product molecular weight 256.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.9 mL||19.51 mL||39.02 mL|
|5 mM||0.78 mL||3.9 mL||7.8 mL|
|10 mM||0.39 mL||1.95 mL||3.9 mL|
|50 mM||0.08 mL||0.39 mL||0.78 mL|
References for OUL 35
References are publications that support the biological activity of the product.
Venkannagari et al (2016) Small-molecule chemical probe rescues cells from mono-ADP-ribosyltransferase ARTD10/PARP10-induced apoptosis and sensitizes cancer cells to DNA damage. Cell Chem.Biol. 23 1251 PMID: 27667561
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Keywords: OUL 35, OUL 35 supplier, OUL35, PARP10, ARTD10, inhibitors, inhibits, ADP-ribosyltransferase, Diptheria, Toxin-like, 10, Poly, (ADP-ribose), polymerase, Poly(ADP-ribose), Polymerase, 6344, Tocris Bioscience
Citations for OUL 35
Citations are publications that use Tocris products.
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Reviews for OUL 35
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Literature in this Area
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.