OUL 35

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Description: Selective PARP-10 inhibitor
Chemical Name: 4,4'-Oxybis[benzamide]
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for OUL 35

OUL 35 is a selective PARP-10 (also known as ADP-ribosyltransferase Diptheria Toxin-like 10, ARTD10) inhibitor (IC50 = 0.329 μM). Displays selectivity for PARP-10 over a panel of PARP family members. Rescues HeLa cells from PARP-10-induced cell death. Sensitizes cancer cells to hydroxyurea-induced genotoxic stress.

Compound Libraries for OUL 35

OUL 35 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for OUL 35

M. Wt 256.26
Formula C14H12N2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 6336-34-1
PubChem ID 236501
Smiles NC(C1=CC=C(C=C1)OC2=CC=C(C(N)=O)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for OUL 35

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.63 100

Preparing Stock Solutions for OUL 35

The following data is based on the product molecular weight 256.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.9 mL 19.51 mL 39.02 mL
5 mM 0.78 mL 3.9 mL 7.8 mL
10 mM 0.39 mL 1.95 mL 3.9 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

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References for OUL 35

References are publications that support the biological activity of the product.

Venkannagari et al (2016) Small-molecule chemical probe rescues cells from mono-ADP-ribosyltransferase ARTD10/PARP10-induced apoptosis and sensitizes cancer cells to DNA damage. Cell Chem.Biol. 23 1251 PMID: 27667561

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Keywords: OUL 35, OUL 35 supplier, OUL35, PARP10, ARTD10, inhibitors, inhibits, ADP-ribosyltransferase, Diptheria, Toxin-like, 10, Poly, (ADP-ribose), polymerase, Poly(ADP-ribose), Polymerase, 6344, Tocris Bioscience

Citations for OUL 35

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Literature in this Area

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