OUL 35

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Cat.No. 6344 - OUL 35 | C14H12N2O3 | CAS No. 6336-34-1
Description: Selective PARP-10 inhibitor
Chemical Name: 4,4'-Oxybis[benzamide]
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective PARP-10 (also known as ADP-ribosyltransferase Diptheria Toxin-like 10, ARTD10) inhibitor (IC50 = 0.329 μM). Displays selectivity for PARP-10 over a panel of PARP family members. Rescues HeLa cells from PARP-10-induced cell death. Sensitizes cancer cells to hydroxyurea-induced genotoxic stress.

Technical Data

M. Wt 256.26
Formula C14H12N2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 6336-34-1
PubChem ID 236501
InChI Key XZRCQWLPMXFGHE-UHFFFAOYSA-N
Smiles NC(C1=CC=C(C=C1)OC2=CC=C(C(N)=O)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 256.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.9 mL 19.51 mL 39.02 mL
5 mM 0.78 mL 3.9 mL 7.8 mL
10 mM 0.39 mL 1.95 mL 3.9 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Venkannagari et al (2016) Small-molecule chemical probe rescues cells from mono-ADP-ribosyltransferase ARTD10/PARP10-induced apoptosis and sensitizes cancer cells to DNA damage. Cell Chem.Biol. 23 1251 PMID: 27667561


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Keywords: OUL 35, supplier, OUL35, PARP10, ARTD10, inhibitors, inhibits, ADP-ribosyltransferase, Diptheria, Toxin-like, 10, Poly, (ADP-ribose), polymerase, Poly(ADP-ribose), Polymerase, Poly(ADP-ribose), Polymerase, Tocris Bioscience

Citations for OUL 35

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Reviews for OUL 35

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Literature in this Area

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