Rucaparib camsylate

Pricing Availability Delivery Time Qty
Cat.No. 6230 - Rucaparib camsylate | C19H18FN3O.C10H16O4S | CAS No. 1327258-57-0
Description: PARP inhibitor
Alternative Names: CO-338
Chemical Name: 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2,ef][2]benzazepin-6-one (1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid
Purity: ≥98% (HPLC)

Biological Activity

PARP inhibitor. Chemosensitizes colorectal cancer cells to temozolomide (Cat.No. 2706) and topotecan (Cat.No. 4562) in vitro and in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 555.66
Formula C19H18FN3O.C10H16O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1327258-57-0
PubChem ID 53356947
Smiles CNCC1=CC=C(C2=C3CCNC(C4=C3C(N2)=CC(F)=C4)=O)C=C1.O=S(C[C@@]5(C6(C)C)CC[C@@H]6CC5=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 55.57 100

Preparing Stock Solutions

The following data is based on the product molecular weight 555.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.8 mL 9 mL 18 mL
5 mM 0.36 mL 1.8 mL 3.6 mL
10 mM 0.18 mL 0.9 mL 1.8 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Thomas et al (2007) Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol.Cancer Ther. 6 945 PMID: 17363489

If you know of a relevant reference for Rucaparib camsylate, please let us know.

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Keywords: Rucaparib camsylate, supplier, PARP, inhibitors, inhibits, Poly(ADP-ribose), Polymerase, chemosentizers, chemosensitizes, CO-338, Poly(ADP-ribose), Polymerase, Poly(ADP-ribose), Polymerase, Tocris Bioscience

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