Rucaparib camsylate

Pricing Availability   Qty
Description: PARP inhibitor
Alternative Names: CO-338
Chemical Name: 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2,ef][2]benzazepin-6-one (1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Rucaparib camsylate

Rucaparib camsylate is a PARP inhibitor. Chemosensitizes colorectal cancer cells to Temozolomide (Cat. No. 2706) and Topotecan (Cat. No. 4562) in vitro and in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Rucaparib camsylate

Rucaparib camsylate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Rucaparib camsylate

M. Wt 555.66
Formula C19H18FN3O.C10H16O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1859053-21-6
PubChem ID 53356947
Smiles CNCC1=CC=C(C2=C3CCNC(C4=C3C(N2)=CC(F)=C4)=O)C=C1.O=S(C[C@@]5(C6(C)C)CC[C@@H]6CC5=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rucaparib camsylate

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 55.57 100

Preparing Stock Solutions for Rucaparib camsylate

The following data is based on the product molecular weight 555.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.8 mL 9 mL 18 mL
5 mM 0.36 mL 1.8 mL 3.6 mL
10 mM 0.18 mL 0.9 mL 1.8 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Rucaparib camsylate

References for Rucaparib camsylate

References are publications that support the biological activity of the product.

Thomas et al (2007) Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol.Cancer Ther. 6 945 PMID: 17363489

If you know of a relevant reference for Rucaparib camsylate, please let us know.

View Related Products by Product Action

View all Poly(ADP-Ribose) Polymerase Inhibitors

Keywords: Rucaparib camsylate, Rucaparib camsylate supplier, PARP, inhibitors, inhibits, Poly(ADP-ribose), Polymerase, chemosentizers, chemosensitizes, CO-338, 6230, Tocris Bioscience

Citations for Rucaparib camsylate

Citations are publications that use Tocris products.

Currently there are no citations for Rucaparib camsylate. Do you know of a great paper that uses Rucaparib camsylate from Tocris? Please let us know.

Reviews for Rucaparib camsylate

There are currently no reviews for this product. Be the first to review Rucaparib camsylate and earn rewards!

Have you used Rucaparib camsylate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.