Veliparib dihydrochloride

Pricing Availability   Qty
Description: High affinity PARP-1 and -2 inhibitor; orally bioavailable
Alternative Names: ABT-888
Chemical Name: 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for Veliparib dihydrochloride

Veliparib dihydrochloride is a high affinity PARP-2 and PARP-1 inhibitor (Ki values are 2.9 and 5.2 nM, respectively). Inhibits repair of radiation-induced DNA damage and sensitizes lung cancer cells to radiation. Also increases autophagy and apoptosis in lung cancer cells. Enhances radiation-induced tumor growth delay in mice bearing lung tumor xenografts. Also chemosensitizer. Potentiates effects of temozolomide (Cat. No. 2706) in a mouse melanoma model. Orally bioavailable and brain penetrant.

Compound Libraries for Veliparib dihydrochloride

Veliparib dihydrochloride is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Veliparib dihydrochloride

M. Wt 317.21
Formula C13H16N4O.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 912445-05-7
PubChem ID 45480520
Smiles C[C@]1(C2=NC3=CC=CC(C(N)=O)=C3N2)CCCN1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Veliparib dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.72 100
water 31.72 100

Preparing Stock Solutions for Veliparib dihydrochloride

The following data is based on the product molecular weight 317.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.76 mL 31.52 mL
5 mM 0.63 mL 3.15 mL 6.3 mL
10 mM 0.32 mL 1.58 mL 3.15 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Veliparib dihydrochloride

References for Veliparib dihydrochloride

References are publications that support the biological activity of the product.

Albert et al (2007) Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin.Cancer Res. 13 3033 PMID: 17505006

Donawho et al (2007) ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin.Cancer Res. 13 2728 PMID: 17473206

If you know of a relevant reference for Veliparib dihydrochloride, please let us know.

View Related Products by Product Action

View all Poly(ADP-Ribose) Polymerase Inhibitors

Keywords: Veliparib dihydrochloride, Veliparib dihydrochloride supplier, PARP-1, 2, inhibitors, inhibits, poly(ADP-ribose), polymerase, radiosensitizers, chemosensitizers, high, affinity, orally, bioavailable, brain, penetrant, ABT888, ABT-888, Poly(ADP-ribose), Polymerase, 7026, Tocris Bioscience

1 Citation for Veliparib dihydrochloride

Citations are publications that use Tocris products. Selected citations for Veliparib dihydrochloride include:

Mai et al (2021) NAD+ bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells. NAR Cancer 3 zcab044 PMID: 34806016

Do you know of a great paper that uses Veliparib dihydrochloride from Tocris? Please let us know.

Reviews for Veliparib dihydrochloride

There are currently no reviews for this product. Be the first to review Veliparib dihydrochloride and earn rewards!

Have you used Veliparib dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.