M2 Receptors

M2 receptors are members of the G-protein-coupled receptor (GPCR) family which are found mostly bound to Gi proteins, generally leading to inhibitory effects. They are one of five muscarinic receptors that act to control the metabotropic functions of acetylcholine in the CNS.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
0383 Arecaidine propargyl ester tosylate
Muscarinic agonist

Antagonists

Cat No Product Name / Activity
1105 AF-DX 116
Selective M2 antagonist
1345 AF-DX 384
Potent M2/M4 antagonist
2292 AQ-RA 741
Selective, high affinity M2 antagonist
1425 (S)-(+)-Dimethindene maleate
M2-selective antagonist

M2 receptors are members of the G-protein-coupled receptor (GPCR) family which are found mostly bound to Gi proteins, generally leading to inhibitory effects. They are one of five muscarinic receptors that act to control the metabotropic functions of acetylcholine (ACh) in the central nervous system (CNS). M2 receptors are densely populated in the heart, airway smooth muscle, the hippocampus and most other brain regions.

Activation of the M2 receptor leads to several responses, including the inhibition of adenylyl cyclase and activation of inward rectifier K+ channels (KIR), and Ca2+-activated K+ channels (KCa). M2 receptor antagonism can slow the speed of depolarization and returning the heart to sinus rhythm after sympathetic nervous system stimulation. Overall, M2 receptors are involved in numerous processes including the control of atrial force of contraction, regulation of the AV node conduction velocity, and have also been implicated in peripheral airway smooth muscle contraction and in cognitive processes such as memory and learning. M2 receptors antagonism has been suggested as a therapeutic target in the treatment of Alzheimer's Disease.

External sources of pharmacological information for M2 Receptors :

Literature for M2 Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
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M2 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human CHRM2 NM_000739 P08172
Mouse Chrm2 NM_203491 Q9ERZ4
Rat Chrm2 NM_031016 P10980