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M5 receptors are members of the G-protein-coupled receptor (GPCR) family which are found mostly bound to Gq proteins. They are the last of five muscarinic receptors that act to control the metabotropic functions of acetylcholine (ACh) in the central nervous system (CNS).
|Cat No||Product Name / Activity|
|Selective positive allosteric modulator of M5 receptors|
|Positive allosteric modulator of M5 receptors|
M5 receptors are members of the G-protein-coupled receptor (GPCR) family which are found mostly bound to Gq proteins. They are the last of five muscarinic receptors that act to control the metabotropic functions of acetylcholine (ACh) in the central nervous system (CNS). M5 receptors are most densely populated in the dopamine-containing neuronal cells of the substantia nigra, hippocampus, cerebral cortex and striatum.
Activation of the M5 receptor leads to several responses, including the activation of ion channels such as K+ and Cl- and the inhibition of adenylyl cyclase. M5 receptor agonism modulates the activity of dopaminergic neurons and the release of dopamine into the striatum, which play an important role in mediating properties of abusive substances such as cocaine. In fact the M5 receptor has been implicated in drug addiction and may represent a therapeutic target. Endothelial M5 receptors also control the ability of acetylcholine to establish vasodilation in vascular beds, dramatically affecting cerebral blood flow.
M5 receptors may also be a potential therapeutic target in the treatment of memory deficits caused by impaired cerebrovascular function.
Tocris offers the following scientific literature for M5 Receptors to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.