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Potent M2/M4 selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 478.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.18 mL||20.89 mL||41.79 mL|
|2.5 mM||0.84 mL||4.18 mL||8.36 mL|
|5 mM||0.42 mL||2.09 mL||4.18 mL|
|25 mM||0.08 mL||0.42 mL||0.84 mL|
References are publications that support the biological activity of the product.
Dopke et al (1995) AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography. J.Pharmacol.Exp.Ther. 274 562 PMID: 7616446
Grailhe et al (2009) Regional changes in the cholinergic system in mice lacking monoamine A. Brain Res.Bull. 78 283 PMID: 19111597
Miller et al (1991) Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors. J.Pharmacol.Exp.Ther. 259 601 PMID: 1941609
If you know of a relevant reference for AF-DX 384, please let us know.
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Keywords: AF-DX 384, AF-DX 384 supplier, Potent, M2/M4, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, AFDX384, M2, 1345, Tocris Bioscience
Citations for AF-DX 384
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.