AF-DX 384

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Description: Potent M2/M4 antagonist
Chemical Name: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for AF-DX 384

AF-DX 384 is a potent M2/M4 selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively).

Technical Data for AF-DX 384

M. Wt 478.64
Formula C27H38N6O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 118290-26-9
PubChem ID 119357
InChI Key MZDYABXXPZNUCT-UHFFFAOYSA-N
Smiles CCCN(CCC)CC1CCCCN1CCNC(=O)N1C2=C(C=CC=C2)C(=O)NC2=C1N=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AF-DX 384

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.93 50
ethanol 4.79 10

Preparing Stock Solutions for AF-DX 384

The following data is based on the product molecular weight 478.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.18 mL 20.89 mL 41.79 mL
2.5 mM 0.84 mL 4.18 mL 8.36 mL
5 mM 0.42 mL 2.09 mL 4.18 mL
25 mM 0.08 mL 0.42 mL 0.84 mL

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Product Datasheets for AF-DX 384

Certificate of Analysis / Product Datasheet
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References for AF-DX 384

References are publications that support the biological activity of the product.

Dopke et al (1995) AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography. J.Pharmacol.Exp.Ther. 274 562 PMID: 7616446

Grailhe et al (2009) Regional changes in the cholinergic system in mice lacking monoamine A. Brain Res.Bull. 78 283 PMID: 19111597

Miller et al (1991) Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors. J.Pharmacol.Exp.Ther. 259 601 PMID: 1941609


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Keywords: AF-DX 384, AF-DX 384 supplier, Potent, M2/M4, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, AFDX384, M2, 1345, Tocris Bioscience

Citations for AF-DX 384

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Literature in this Area

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