AQ-RA 741

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Description: High affinity and selective M2 antagonist
Chemical Name: 11-[[4-[4-(Diethylamino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for AQ-RA 741

AQ-RA 741 is a high affinity, selective muscarinic M2 receptor antagonist (pKi values are 8.3, 7.7 and 6.82 for M2, M1 and M3 receptors, respectively). Displays cardioselectivity in vivo, over intestinal, tracheal and bladder muscarinic receptors; inhibits vagally and agonist-induced bradycardia.

Compound Libraries for AQ-RA 741

AQ-RA 741 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AQ-RA 741

M. Wt 463.62
Formula C27H37N5O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 123548-16-3
PubChem ID 129989

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AQ-RA 741

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 46.36 100
DMSO 46.36 100
ethanol 46.36 100

Preparing Stock Solutions for AQ-RA 741

The following data is based on the product molecular weight 463.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.78 mL 21.57 mL
5 mM 0.43 mL 2.16 mL 4.31 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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References for AQ-RA 741

References are publications that support the biological activity of the product.

Doods et al (1991) Cardioselectivity of AQ-RA 741, a novel tricyclic antimuscarinic drug. Eur.J.Pharmacol. 192 147 PMID: 2040358

Dorje et al (1991) Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J.Pharmacol.Exp.Ther. 256 727 PMID: 1994002

Doods et al (1994) Pharmacological profile of selective muscarinic receptor antagonists on guinea-pig ileal smooth muscle. Eur.J.Pharmacol. 253 275 PMID: 8200421

If you know of a relevant reference for AQ-RA 741, please let us know.

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Keywords: AQ-RA 741, AQ-RA 741 supplier, Selective, high, affinity, M2, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, AQRA741, 2292, Tocris Bioscience

Citations for AQ-RA 741

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.