AQ-RA 741

Pricing Availability Delivery Time Qty
Cat.No. 2292 - AQ-RA 741 | C27H37N5O2 | CAS No. 123548-16-3
Description: Selective, high affinity M2 antagonist
Chemical Name: 11-[[4-[4-(Diethylamino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity, selective muscarinic M2 receptor antagonist (pKi values are 8.3, 7.7 and 6.82 for M2, M1 and M3 receptors, respectively). Displays cardioselectivity in vivo, over intestinal, tracheal and bladder muscarinic receptors; inhibits vagally and agonist-induced bradycardia.

Compound Libraries

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Technical Data

M. Wt 463.62
Formula C27H37N5O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 123548-16-3
PubChem ID 129989
InChI Key BCUGCHZRMKTPMU-UHFFFAOYSA-N
Smiles CCN(CC)CCCCC1CCN(CC(=O)N2C3=CC=CC=C3C(=O)NC3=C2N=CC=C3)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 46.36 100
DMSO 46.36 100
ethanol 46.36 100

Preparing Stock Solutions

The following data is based on the product molecular weight 463.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.78 mL 21.57 mL
5 mM 0.43 mL 2.16 mL 4.31 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Doods et al (1991) Cardioselectivity of AQ-RA 741, a novel tricyclic antimuscarinic drug. Eur.J.Pharmacol. 192 147 PMID: 2040358

Dorje et al (1991) Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J.Pharmacol.Exp.Ther. 256 727 PMID: 1994002

Doods et al (1994) Pharmacological profile of selective muscarinic receptor antagonists on guinea-pig ileal smooth muscle. Eur.J.Pharmacol. 253 275 PMID: 8200421


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Keywords: AQ-RA 741, supplier, Selective, high, affinity, M2, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, AQRA741, M2, Receptors, Tocris Bioscience

Citations for AQ-RA 741

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