You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Positive allosteric modulator of M2 and M4 muscarinic receptors. Potentiates activity of agonist at receptor in G protein-coupled functional assay. Cooperativity factor, α = 19.5 and 79.4 for M2 and M4 in presence of ACh, respectively. Binds in extracellular site.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 437.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.28 mL||11.42 mL||22.83 mL|
|5 mM||0.46 mL||2.28 mL||4.57 mL|
|10 mM||0.23 mL||1.14 mL||2.28 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References are publications that support the biological activity of the product.
Croy et al (2014) Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M2 and M4 receptors. Mol.Pharmacol. 86 106 PMID: 24807965
Kruse et al (2013) Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature 504 101 PMID: 24256733
If you know of a relevant reference for LY 2119620, please let us know.
View Related Products by Product Action
Keywords: LY 2119620, LY 2119620 supplier, LY2119620, muscarinic, acetylcholine, ach, receptor, M2, M4, positive, allosteric, modulators, PAM, potentiates, modulates, mAChRs, Receptors, 6964, Tocris Bioscience
Citations for LY 2119620
Citations are publications that use Tocris products.
Currently there are no citations for LY 2119620. Do you know of a great paper that uses LY 2119620 from Tocris? Please let us know.
Reviews for LY 2119620
There are currently no reviews for this product. Be the first to review LY 2119620 and earn rewards!
Have you used LY 2119620?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.