LY 2119620

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Cat.No. 6964 - LY 2119620 | C19H24ClN5O3S | CAS No. 886047-22-9
Description: Positive allosteric modulator of M2 and M4 receptors
Chemical Name: 3-Amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity

Positive allosteric modulator of M2 and M4 muscarinic receptors. Potentiates activity of agonist at receptor in G protein-coupled functional assay. Cooperativity factor, α = 19.5 and 79.4 for M2 and M4 in presence of ACh, respectively. Binds in extracellular site.

Technical Data

M. Wt 437.94
Formula C19H24ClN5O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 886047-22-9
PubChem ID 57664406
InChI Key TYTGOXSAAQWLPJ-UHFFFAOYSA-N
Smiles CN1CCN(CC1)C(=O)COC1=C(Cl)C(C)=C2C(N)=C(SC2=N1)C(=O)NC1CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.79 100
1eq. HCl 43.79 100

Preparing Stock Solutions

The following data is based on the product molecular weight 437.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.42 mL 22.83 mL
5 mM 0.46 mL 2.28 mL 4.57 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References

References are publications that support the biological activity of the product.

Croy et al (2014) Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M2 and M4 receptors. Mol.Pharmacol. 86 106 PMID: 24807965

Kruse et al (2013) Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature 504 101 PMID: 24256733


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Keywords: LY 2119620, LY 2119620 supplier, LY2119620, muscarinic, acetylcholine, ach, receptor, M2, M4, positive, allosteric, modulators, PAM, potentiates, modulates, mAChRs, Receptors, 6964, Tocris Bioscience

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