LY 2119620

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Description: Positive allosteric modulator of M2 and M4 receptors
Chemical Name: 3-Amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for LY 2119620

LY 2119620 is a positive allosteric modulator of M2 and M4 muscarinic receptors. Potentiates activity of agonist at receptor in G protein-coupled functional assay. Cooperativity factor, α = 19.5 and 79.4 for M2 and M4 in presence of ACh, respectively. Binds in extracellular site.

Technical Data for LY 2119620

M. Wt 437.94
Formula C19H24ClN5O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 886047-22-9
PubChem ID 57664406
Smiles CN1CCN(CC1)C(=O)COC1=C(Cl)C(C)=C2C(N)=C(SC2=N1)C(=O)NC1CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LY 2119620

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.79 100
1eq. HCl 43.79 100

Preparing Stock Solutions for LY 2119620

The following data is based on the product molecular weight 437.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.42 mL 22.83 mL
5 mM 0.46 mL 2.28 mL 4.57 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for LY 2119620

References are publications that support the biological activity of the product.

Croy et al (2014) Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M2 and M4 receptors. Mol.Pharmacol. 86 106 PMID: 24807965

Kruse et al (2013) Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature 504 101 PMID: 24256733

If you know of a relevant reference for LY 2119620, please let us know.

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Keywords: LY 2119620, LY 2119620 supplier, LY2119620, muscarinic, acetylcholine, ach, receptor, M2, M4, positive, allosteric, modulators, PAM, potentiates, modulates, mAChRs, Receptors, 6964, Tocris Bioscience

Citations for LY 2119620

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Literature in this Area

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