M1 Receptors

M1 receptors are members of the G-protein-coupled receptor (GPCR) family which are found mostly bound to Gq proteins. They are one of five muscarinic receptors that act to control the metabotropic functions of acetylcholine (ACh) in the central nervous system (CNS).

Products
Background
Literature (1)
Gene Data

M1 Receptor Agonists

Cat. No. Product Name / Activity
3689 Cevimeline hydrochloride
Selective M1 agonist
1384 McN-A 343
Selective M1 muscarinic agonist
3569 Xanomeline oxalate
M1 and M4 receptor agonist

M1 Receptor Antagonists

Cat. No. Product Name / Activity
2853 Biperiden hydrochloride
Muscarinic receptor antagonist; some selectivity for M1
1071 Pirenzepine dihydrochloride
Selective M1 antagonist
1122 Telenzepine dihydrochloride
Potent, selective M1 antagonist
3727 VU 0255035
Highly selective M1 antagonist

M1 Receptor Modulators

Cat. No. Product Name / Activity
4295 VU 0357017 hydrochloride
Positive allosteric modulator of M1 receptors

M1 receptors are members of the G-protein-coupled receptor (GPCR) family which are found mostly bound to Gq proteins. They are one of five muscarinic receptors that act to control the metabotropic functions of acetylcholine (ACh) in the central nervous system (CNS). M1 receptors are most densely populated in the neuronal cells of the cerebral cortex and hippocampus. Activation of the M1 receptor leads to several responses, including the upregulation of phospholipase C, the activation of ion channels such as K+ and Cl- and the inhibition of cAMP production. M1 receptor agonism can also lead to secretion (from the salivary gland, or stomach) and bronchoconstriction. Overall, M1 receptors are involved in numerous processes including the control of seizures, regulation the force of cardiac muscle contraction and most importantly mediating cognitive processes such as memory and learning.

M1 receptors are a well-known therapeutic target in the treatment of Alzheimer's Disease. Activation of the M1 receptor by selective agonists increases the secretion of non-toxic α-amyloid peptide and decreases harmful β-amyloid secretion from amyloid precursor proteins.

External sources of pharmacological information for M1 Receptors :

Literature for M1 Receptors

Tocris offers the following scientific literature for M1 Receptors to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

M1 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human CHRM1 NM_000738 P11229
Mouse Chrm1 NM_001112697 P12657
Rat Chrm1 NM_080773 P08482