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Biological Activity for Quetiapine hemifumarate
Quetiapine hemifumarate is an atypical antipsychotic. Displays antagonist activity at serotonin (5-HT2) and dopamine (D2) receptors (IC50 values are 148 and 329 nM respectively). Lacks affinity at either D1 or muscarinic receptors.
Compound Libraries for Quetiapine hemifumarate
Technical Data for Quetiapine hemifumarate
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Quetiapine hemifumarate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Quetiapine hemifumarate
The following data is based on the product molecular weight 441.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.53 mL||22.65 mL||45.3 mL|
|2.5 mM||0.91 mL||4.53 mL||9.06 mL|
|5 mM||0.45 mL||2.26 mL||4.53 mL|
|25 mM||0.09 mL||0.45 mL||0.91 mL|
Product Datasheets for Quetiapine hemifumarate
References for Quetiapine hemifumarate
References are publications that support the biological activity of the product.
Saller and Salama (1993) Seroquel: biochemical profile of a potential atypical antipsychotic. Psychopharmacology (Berl.) 112 285 PMID: 7871032
Ellenbroek et al (1996) Activity of "seroquel" (ICI 204,636) in animal models for atypical properties of antipsychotics: a comparison with cloz. Neuropsychopharmacology 15 406 PMID: 8887995
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Citations for Quetiapine hemifumarate
Citations are publications that use Tocris products.
Currently there are no citations for Quetiapine hemifumarate. Do you know of a great paper that uses Quetiapine hemifumarate from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.