Quetiapine hemifumarate

Pricing Availability   Qty
Description: 5-HT2 antagonist; also D2 antagonist; atypical antipsychotic
Alternative Names: ICI 204,636
Chemical Name: 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for Quetiapine hemifumarate

Quetiapine hemifumarate is an atypical antipsychotic. Displays antagonist activity at serotonin (5-HT2) and dopamine (D2) receptors (IC50 values are 148 and 329 nM respectively). Lacks affinity at either D1 or muscarinic receptors.

Compound Libraries for Quetiapine hemifumarate

Quetiapine hemifumarate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Quetiapine hemifumarate

M. Wt 441.54
Formula C21H25N3O2S.0.5C4H4O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 111974-72-2
PubChem ID 5281025

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Quetiapine hemifumarate

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 22.08 50

Preparing Stock Solutions for Quetiapine hemifumarate

The following data is based on the product molecular weight 441.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.53 mL 22.65 mL 45.3 mL
2.5 mM 0.91 mL 4.53 mL 9.06 mL
5 mM 0.45 mL 2.26 mL 4.53 mL
25 mM 0.09 mL 0.45 mL 0.91 mL

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Product Datasheets for Quetiapine hemifumarate

References for Quetiapine hemifumarate

References are publications that support the biological activity of the product.

Saller and Salama (1993) Seroquel: biochemical profile of a potential atypical antipsychotic. Psychopharmacology (Berl.) 112 285 PMID: 7871032

Ellenbroek et al (1996) Activity of "seroquel" (ICI 204,636) in animal models for atypical properties of antipsychotics: a comparison with cloz. Neuropsychopharmacology 15 406 PMID: 8887995

If you know of a relevant reference for Quetiapine hemifumarate, please let us know.

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Citations for Quetiapine hemifumarate

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.