Sumanirole maleate

Pricing Availability Delivery Time Qty
Cat.No. 2773 - Sumanirole maleate | C11H13N3O.C4H4O4 | CAS No. 179386-44-8
Description: D2-selective agonist
Chemical Name: (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (2Z)-2-butenedioate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity D2 receptor agonist (EC50 values are between 17 and 75 nM in cell-based assays). Displays >200-fold selectivity for the D2 receptor against other dopamine receptor subtypes (Ki values are 9.0, 1940, >2190 and >7140 for D2, D3, D4 and D1 receptors respectively). Exhibits antiParkinsonian activity similar to ropinirole (Cat. No. 3680).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 319.31
Formula C11H13N3O.C4H4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 179386-44-8
PubChem ID 9818478
InChI Key VOJRMYBBPKNLLI-ORHWHDKWSA-N
Smiles O=C3N2C1=C(N3)C=CC=C1C[C@@H](NC)C2.O=C(/C=C\C(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.93 100
water 31.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 319.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.13 mL 15.66 mL 31.32 mL
5 mM 0.63 mL 3.13 mL 6.26 mL
10 mM 0.31 mL 1.57 mL 3.13 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

McCall et al (2005) Sumanirole, a highly dopamine D2-selective receptor agonist: in vitro and in vivo pharmacological characterization and efficacy in animal models of Parkinson's disease. J.Pharmacol.Exp.Ther. 314 1248 PMID: 15980060

Stephenson et al (2005) The effects of a selective dopamine D2 receptor agonist on behavioral and pathological outcome in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated squirrel monkeys. J.Pharmacol.Exp.Ther. 314 1257 PMID: 15980058


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Keywords: pfizer dopamine dopaminergic receptors d2 selective antiparkinsonian parkinsons parkinson's D2 Receptors

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