Aripiprazole

Pricing Availability Delivery Time Qty
Cat.No. 5584 - Aripiprazole | C23H27Cl2N3O2 | CAS No. 129722-12-9
Description: High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist
Chemical Name: 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity dopamine D2 and 5-HT1A receptor partial agonist (Ki values are ~1.64 and 5.59 nM respectively). Also 5-HT2A antagonist (Ki = 8.7 nM). Suppresses morphine-induced emesis in vivo. Atypical antipsychotic.

Compound Libraries

Aripiprazole is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 448.39
Formula C23H27Cl2N3O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 129722-12-9
PubChem ID 60795
InChI Key CEUORZQYGODEFX-UHFFFAOYSA-N
Smiles O=C2CCC1=CC=C(OCCCCN3CCN(C4=CC=CC(Cl)=C4Cl)CC3)C=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 448.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.15 mL 22.3 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
10 mM 0.22 mL 1.12 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Davies et al (2004) Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology. CNS Drug Rev. 10 317 PMID: 15592581

Shiokawa et al (2007) Usefulness of the dopamine system-stabilizer aripiprazole for reducing morphine-induced emesis. Eur.J.Pharmacol. 570 108 PMID: 17678644


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Keywords: Aripiprazole, supplier, high, affinity, dopamine, D2, 5-ht1a, 5-ht2a, partial, agonists, antagonists, antipsychotic, D2, Receptors, 5-HT1A, Receptors, 5-HT2A, Receptors, D2, Receptors, Tocris Bioscience

Citations for Aripiprazole

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