Olanzapine

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Cat.No. 4349 - Olanzapine | C17H20N4S | CAS No. 132539-06-1
Description: 5-HT2A antagonist; also D2 antagonist; atypical antipsychotic
Chemical Name: 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Antagonist of 5-HT2A and dopamine D2 receptors (Ki values are 4 and 11 nM respectively). Also displays affinity for a range of other receptors including D1 and D4, 5-HT2C, α1, H1 and M1-4 receptors (Ki values range between 1.9 and 31 nM). Atypical antipsychotic. Displays anticholinergic properties. Also a highly potent activator of hM4Di DREADDs (EC50 values are 5 nM in vitro and 7 nM in vivo).

Compound Libraries

Olanzapine is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 312.43
Formula C17H20N4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 132539-06-1
PubChem ID 4585
InChI Key WXPNDRBBWZMPQG-UHFFFAOYSA-N
Smiles CC4=CC2=C(S4)NC1=CC=CC=C1N=C2N3CCN(C)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.24 100
1eq. HCl 31.24 100

Preparing Stock Solutions

The following data is based on the product molecular weight 312.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.2 mL 16 mL 32.01 mL
5 mM 0.64 mL 3.2 mL 6.4 mL
10 mM 0.32 mL 1.6 mL 3.2 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Tollefson and Taylor (2000) Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent. CNS Drug Reviews 6 303

Moore et al (1992) The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent. J.Pharmacol.Exp.Ther. 262 545 PMID: 1354253

Bymaster et al (1996) Radioreceptor binding profile of the atypical antipsychotic olanz. Neuropsychopharmacology 14 87 PMID: 8822531


If you know of a relevant reference for Olanzapine, please let us know.

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View all 5-HT2A Receptor Antagonists

Keywords: Olanzapine, Olanzapine supplier, 5ht2a, 5ht2c, serotonergics, dopamine, dopaminergics, d2, antagonists, atypical, antipsychotics, thienobenzodiazepine, D2, Receptors, DREADDs, 5-HT2A, 4349, Tocris Bioscience

3 Citations for Olanzapine

Citations are publications that use Tocris products. Selected citations for Olanzapine include:

Joshi and Panicker (2019) Identifying the In Vivo Cellular Correlates of Antipsychotic Drugs. Eneuro 5 PMID: 30713996

Pérez-Gómez et al (2018) A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia. Nat Commun 9 5272 PMID: 30532051

Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Nat Methods 40 766 PMID: 25249058


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Literature in this Area

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