Risperidone

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Cat.No. 2865 - Risperidone | C23H27FN4O2 | CAS No. 106266-06-2
Description: 5-HT2A antagonist
Alternative Names: R 64 766
Chemical Name: 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Atypical antipsychotic agent that displays 5-HT2A receptor antagonism. Also displays high affinity at D2 receptors (Ki values are 0.4 and 3.13 nM for 5-HT2A and D2 receptors respectively).

Technical Data

M. Wt 410.48
Formula C23H27FN4O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 106266-06-2
PubChem ID 5073
InChI Key RAPZEAPATHNIPO-UHFFFAOYSA-N
Smiles FC1=CC2=C(C(C3CCN(CCC4=C(C)N=C(CCCC5)N5C4=O)CC3)=NO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.1 10
ethanol 4.1 10

Preparing Stock Solutions

The following data is based on the product molecular weight 410.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.18 mL 24.36 mL
5 mM 0.49 mL 2.44 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Leysen et al (1988) Biochemical profile of risperidone, a new antipsychotic. J.Pharmacol.Exp.Ther. 247 661 PMID: 2460616

Leysen et al (1994) Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J.Clin.Psychiatry 55 5 PMID: 7520908

Stathis et al (1996) Risperidone: a novel antipsychotic with many "atypical" properties. Psychopharmacol. 127 181 PMID:


If you know of a relevant reference for Risperidone, please let us know.

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Keywords: Risperidone, supplier, 5-HT2A, antagonists, D2, Serotonin, Receptors, Dopamine, dopaminergic, R64766, R, 64, 766, 5-HT2A, Receptors, Tocris Bioscience

1 Citation for Risperidone

Citations are publications that use Tocris products. Selected citations for Risperidone include:

Canfrán-Duque et al (2015) Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro. Sci Rep 10 e0141829 PMID: 26517556


Do you know of a great paper that uses Risperidone from Tocris? If so please let us know.

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5-HT Receptors Scientific Review

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Pathways for Risperidone

Protocols

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