Pricing Availability   Qty
Description: 5-HT2A antagonist; also D2 antagonist; atypical antipsychotic
Alternative Names: R 64 766
Chemical Name: 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Purity: ≥99% (HPLC)
Citations (2)
Reviews (1)
Literature (3)

Biological Activity for Risperidone

Risperidone is an atypical antipsychotic agent that displays 5-HT2A receptor antagonism. Also displays high affinity at D2 receptors (Ki values are 0.4 and 3.13 nM for 5-HT2A and D2 receptors respectively).

Technical Data for Risperidone

M. Wt 410.48
Formula C23H27FN4O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 106266-06-2
PubChem ID 5073
Smiles FC1=CC2=C(C(C3CCN(CCC4=C(C)N=C(CCCC5)N5C4=O)CC3)=NO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Risperidone

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.1 10
ethanol 4.1 10

Preparing Stock Solutions for Risperidone

The following data is based on the product molecular weight 410.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.36 mL 121.81 mL 243.62 mL
0.5 mM 4.87 mL 24.36 mL 48.72 mL
1 mM 2.44 mL 12.18 mL 24.36 mL
5 mM 0.49 mL 2.44 mL 4.87 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for Risperidone

References are publications that support the biological activity of the product.

Leysen et al (1988) Biochemical profile of risperidone, a new antipsychotic. J.Pharmacol.Exp.Ther. 247 661 PMID: 2460616

Leysen et al (1994) Risperidone: a novel antipsychotic with balanced serotonin-DA antagonism, receptor occupancy profile, and pharmacologic activity. J.Clin.Psychiatry 55 5 PMID: 7520908

Stathis et al (1996) Risperidone: a novel antipsychotic with many "atypical" properties. Psychopharmacol. 127 181

Wang et al (2018) Structure of the D2 DA receptor bound to the atypical antipsychotic drug risperidone Nature 555 269 PMID: 29466326

If you know of a relevant reference for Risperidone, please let us know.

View Related Products by Product Action

View all 5-HT2A Receptor Antagonists

Keywords: Risperidone, Risperidone supplier, 5-HT2A, antagonists, D2, Serotonin, Receptors, Dopamine, dopaminergic, R64766, R, 64, 766, 2865, Tocris Bioscience

2 Citations for Risperidone

Citations are publications that use Tocris products. Selected citations for Risperidone include:

Kurita et al (2012) HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci 15 1245 PMID: 22864611

Canfrán-Duque et al (2015) Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro. Sci Rep 10 e0141829 PMID: 26517556

Do you know of a great paper that uses Risperidone from Tocris? Please let us know.

Reviews for Risperidone

Average Rating: 4 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used Risperidone?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Risperidone effects in mice hyperactivity.
By Anonymous on 01/11/2019
Assay Type: In Vivo
Species: Mouse

We found that risperidone treatment decreased hyperactivity of NF-kappa B p50 subunit KO mice, but had no effect on defective social interaction. Altogether, these data add complexity to a growing body of data, suggesting a link between dysregulation of the NF-kappa B pathway and neurodevelopmental disorders pathogenesis.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.