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Description: Potent and partially selective hD2 dopamine receptor fluorescent antagonist
Purity: ≥95% (HPLC)
Literature (2)

Biological Activity for CELT-426

CELT-426 is a potent and partially selective fluorescent hD2 dopamine receptor antagonist (Ki values are 89.3 nM, 194.8 nM, and 263.6 nM for D2, D3, and D4 dopamine receptors respectively in radioligand binding assay). CELT-426 can be used as a fluorescent dopamine receptor probe for fluorescence binding assays, live cell imaging, flow cytometry, and fluorescence polarization assays. It is a suitable replacement for GPCR radiolabeling ligands. Excitation and emission maxima (λ) are 560 and 571 nm, respectively. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor 1 (Cat. No. 7920) TR-FRET donor.

Add 62 μL of assay buffer containing 1% of DMSO to obtain a 100 μM stock solution, and use 250 nM as working concentration.

Scientific Data

Competition Assay Application of CELT-426 in high content screening assay. View Larger

Application of CELT-426 in high content screening assay. Competition binding assay between CELT-426 (100 nM) and increasing concentrations of haloperidol (Catalog # 0931) in live adherent CHO cells expressing hD2.

Application of CELT-426 in fluorescence polarization assay. Human dopamine D2 receptor was isolated from CHO cells by membrane preparation and incubated with CELT-426 (100 nM). Haloperidol (Catalog # 0931) was added across a range of concentrations, and the binding affinity (KD = 3 nM) determined by fluorescence polarization.

Licensing Information

Sold under license from Celtarys Research

Optical Data for CELT-426

Emission Color Yellow
λabs 560 nm
λem 571 nm
Closest Laser line 561 nm
Application Fluorescence polarization, Confocal microscopy, Flow Cytometry, High-content screening,

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Technical Data for CELT-426

M. Wt 1615.85
Storage Store at -20°C
Purity ≥95% (HPLC)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for CELT-426

References are publications that support the biological activity of the product.

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Keywords: CELT-426, CELT-426 supplier, CELT-426, hD2, dopamine, receptors, fluorescent, antagonist, probe, Fluorescent, Receptor, Probes, D2, Receptors, TR-FRET, and, FP, Assay, Reagents, 7955, Tocris Bioscience

Citations for CELT-426

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