SR 58611A hydrochloride

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Cat.No. 3986 - SR 58611A hydrochloride | C22H26ClNO4.HCl | CAS No. 121524-09-2
Description: β3 agonist; displays anxiolytic and antidepressant effects
Chemical Name: [[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]ox]yacetic acid ethyl ester hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective β3-adrenergic receptor agonist. Displays both anxiolytic and antidepressant effects in rodent models. Orally active and brain penetrant.

Compound Libraries

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Technical Data

M. Wt 440.36
Formula C22H26ClNO4.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 121524-09-2
PubChem ID 121888
InChI Key NQIZCDQCNYCVAS-RQBPZYBGSA-N
Smiles O=C(OCC)COC1=CC=C(CC[C@H](NC[C@H](O)C3=CC(Cl)=CC=C3)C2)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.04 100

Preparing Stock Solutions

The following data is based on the product molecular weight 440.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.35 mL 22.71 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.14 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Consoli et al (2007) Behavioral effects of the β3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs? Eur.J.Pharmacol 573 139 PMID: 17669397

Claustre et al (2008) Effects of the β3-adrenoceptor (Adrb3) agonist SR58611A (amibegron) on serotonergic and noradrenergic transmission in the rodent: relevance to its antidepressant/anxiolytic-like profile. Neuroscience 156 353 PMID: 18691638

Stemmelin et al (2008) Stimulation of the β3-adrenoceptor as a novel treatment strategy for anxiety and depressive disorders. Neuropsychopharmacology 33 574 PMID: 17460614

Tamburella et al (2010) The beta(3) adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes. Eur.Neuropsychopharmacol. 20 704 PMID: 20537869


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Keywords: SR58611A HCl adrenoceptor adrenergic receptor b3 beta3 β3 agonists anxiolytics antidepressants Adrenergic Beta-3 Receptors

Citations for SR 58611A hydrochloride

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Literature in this Area

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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Pathways for SR 58611A hydrochloride

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