Mirabegron

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Cat.No. 7070 - Mirabegron | C21H24N4O2S | CAS No. 223673-61-8
Description: Potent and selective β3 agonist
Chemical Name: 2-Amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

Potent and selective β3-adrenoceptor agonist (EC50 = 22.4 nM). Displays >440-fold selectivity for β3 over β1 and β2 adrenoceptors. Increases cAMP concentration in CHO cells expressing human β3-adrenoceptor. Displays relaxant effect in ex vivo rat bladder muscle preparation precontracted with carbachol (Cat. No. 2810). Decreases frequency of bladder contraction in rats. Also promotes browning of white adipose tissue, reduces body weight, and improves glucose tolerance and insulin sensitivity in mice fed a high fat diet.

Technical Data

M. Wt 396.51
Formula C21H24N4O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 223673-61-8
PubChem ID 9865528
InChI Key PBAPPPCECJKMCM-IBGZPJMESA-N
Smiles NC1=NC(CC(=O)NC2=CC=C(CCNC[C@H](O)C3=CC=CC=C3)C=C2)=CS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.65 100
ethanol 7.93 20

Preparing Stock Solutions

The following data is based on the product molecular weight 396.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.61 mL 25.22 mL
5 mM 0.5 mL 2.52 mL 5.04 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References

References are publications that support the biological activity of the product.

Takasu et al (2007) Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective β3-adrenoceptor agonist, on bladder function. J.Pharmacol.Exp.Ther. 321 642 PMID: 17293563

Hao et al (2019) Beneficial metabolic effects of mirabegron in vitro and in high-fat diet-induced obese mice. J.Pharmacol.Exp.Ther. 369 419 PMID: 30940691

Sui et al (2019) Bladder drug mirabegron exacerbates atherosclerosis through activation of brown fat-mediated lipolysis. Proc.Natl.Acad.Sci.U.S.A. 116 10937 PMID: 31085638


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Citations for Mirabegron

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Literature in this Area

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