Pricing Availability   Qty
Description: Potent and selective β3 agonist
Chemical Name: 2-Amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for Mirabegron

Mirabegron is a potent and selective β3-adrenoceptor agonist (EC50 = 22.4 nM). Displays >440-fold selectivity for β3 over β1 and β2 adrenoceptors. Increases cAMP concentration in CHO cells expressing human β3-adrenoceptor. Displays relaxant effect in ex vivo rat bladder muscle preparation precontracted with carbachol (Cat. No. 2810). Decreases frequency of bladder contraction in rats. Also promotes browning of white adipose tissue, reduces body weight, and improves glucose tolerance and insulin sensitivity in mice fed a high fat diet.

Compound Libraries for Mirabegron

Mirabegron is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Mirabegron

M. Wt 396.51
Formula C21H24N4O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 223673-61-8
PubChem ID 9865528
Smiles NC1=NC(CC(=O)NC2=CC=C(CCNC[C@H](O)C3=CC=CC=C3)C=C2)=CS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Mirabegron

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.65 100
ethanol 7.93 20

Preparing Stock Solutions for Mirabegron

The following data is based on the product molecular weight 396.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.61 mL 25.22 mL
5 mM 0.5 mL 2.52 mL 5.04 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References for Mirabegron

References are publications that support the biological activity of the product.

Takasu et al (2007) Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective β3-adrenoceptor agonist, on bladder function. J.Pharmacol.Exp.Ther. 321 642 PMID: 17293563

Hao et al (2019) Beneficial metabolic effects of mirabegron in vitro and in high-fat diet-induced obese mice. J.Pharmacol.Exp.Ther. 369 419 PMID: 30940691

Sui et al (2019) Bladder drug mirabegron exacerbates atherosclerosis through activation of brown fat-mediated lipolysis. Proc.Natl.Acad.Sci.U.S.A. 116 10937 PMID: 31085638

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Citations for Mirabegron

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.