CL 316243 disodium salt
Potent and highly selective β3-adrenoceptor agonist (EC50 = 3 nM); > 10000-fold selective over β1 and β2 receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 465.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.15 mL||10.73 mL||21.47 mL|
|5 mM||0.43 mL||2.15 mL||4.29 mL|
|10 mM||0.21 mL||1.07 mL||2.15 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References are publications that support the products' biological activity.
Bloom et al (1992) Disodium(R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent β-adrenergic agonist virtually specific for β3 receptors. A promising antidiabetic and a J.Med.Chem. 35 3081 PMID: 1354264
Woods et al (2001) Efficacy of the β3-adrenergic receptor agonist CL-316243 on experimental bladder hyperflexia and detrusor instability in the rat. J.Urol. 166 1142 PMID: 11490313
Yoshida et al (1994) Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific β3-adrenoceptor agonist, in yellow KK mice. Life Sci. 54 491 PMID: 8309351
If you know of a relevant reference for CL 316243 disodium salt, please let us know.
View Related Products by Product Action
Keywords: CL 316243 disodium salt, supplier, selective, β3-adrenoceptor, b3-adrenoceptor, β3-adrenergic, b3-adrenergic, agonists, Receptors, CL316243, disodium, salt, Adrenergic, Beta-3, Receptors, Adrenergic, Beta-3, Receptors, Tocris Bioscience
13 Citations for CL 316243 disodium salt
Citations are publications that use Tocris products. Selected citations for CL 316243 disodium salt include:
Enriori et al (2011) Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. Am J Pathol 31 12189 PMID: 21865462
Huang et al (2017) Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation. Nat Commun 8 68 PMID: 28701693
Mössenböck et al (2014) Browning of white adipose tissue uncouples glucose uptake from insulin signaling. PLoS One 9 e110428 PMID: 25313899
Suárez et al (2014) Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech 7 129 PMID: 24159189
Pan et al (2014) MicroRNA-378 controls classical brown fat expansion to counteract obesity. Nat Commun 5 4725 PMID: 25145289
Li (2017) An additive effect of promoting thermogenic gene expression in mice adipose-derived stromal vascular cells by combination of rosiglitazone and CL316,243 Int J Mol Sci 18 E1002 PMID: 28481288
Chen et al (2016) Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity. Bladder (San Franc) 7 11420 PMID: 27117818
Kashyap et al (2015) Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation. Cell Rep 2 PMID: 26709376
Patsouris et al (2015) Burn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans. Nat Commun 13 1538 PMID: 26586436
Berbée et al (2015) Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. J Neurosci 6 6356 PMID: 25754609
Rieg et al (2012) Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices. PLoS One 6 e29698 PMID: 22216346
Nackley et al (2007) Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain 128 199 PMID: 17084978
Nagai et al (2015) Pulmonary Macrophages Attenuate Hypoxic Pulmonary Vasoconstriction via β3AR/iNOS Pathway in Rats Exposed to Chronic Intermittent Hypoxia. PLoS One 10 e0131923 PMID: 26132492
Do you know of a great paper that uses CL 316243 disodium salt from Tocris? If so please let us know.
Reviews for CL 316243 disodium salt
There are currently no reviews for this product. Be the first to review CL 316243 disodium salt and earn rewards!
Have you used CL 316243 disodium salt?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.