BRL 37344, sodium salt

Pricing Availability   Qty
Description: β3 agonist
Chemical Name: (R*,R*)-(±)-4-[2-[(2-(3-Chlorophenyl)-2-hydroxyethyl)amino]propyl]phenoxyacetic acid, sodium salt
Purity: ≥98% (HPLC)
Citations (10)
Literature (1)

Biological Activity for BRL 37344, sodium salt

BRL 37344, sodium salt is a potent and selective β3 adrenoceptor agonist (Ki values are 287, 1750 and 1120 nM for β3, β1 and β2 receptors respectively).

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data for BRL 37344, sodium salt

M. Wt 385.82
Formula C19H21NO4ClNa
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 127299-93-8
PubChem ID 16219010
Smiles [Na+].C[C@H](CC1=CC=C(OCC([O-])=O)C=C1)NC[C@H](O)C1=CC(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BRL 37344, sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
water 38.58 100

Preparing Stock Solutions for BRL 37344, sodium salt

The following data is based on the product molecular weight 385.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.96 mL 25.92 mL
5 mM 0.52 mL 2.59 mL 5.18 mL
10 mM 0.26 mL 1.3 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets for BRL 37344, sodium salt

Certificate of Analysis / Product Datasheet
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References for BRL 37344, sodium salt

References are publications that support the biological activity of the product.

Arch et al (1984) Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 309 163 PMID: 6325935

Ayo Oriowo et al (1996) The selectivity in vitro of the sterioisomers of the beta-3 adrenoreceptor agonist BRL 37344. J.Pharmacol.Exp.Ther. 277 22 PMID: 8613923

Board et al (2000) BRL37344, but not CGP12177, stimulates fuel oxidation by soleus muscle in vitro. Eur.J.Pharmacol. 406 33 PMID: 11011029

Strosberg and Pietri-Rouxel (1996) Function and regulation of the β3-adrenoceptor. TiPS 17 373 PMID: 8979772

If you know of a relevant reference for BRL 37344, sodium salt, please let us know.

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10 Citations for BRL 37344, sodium salt

Citations are publications that use Tocris products. Selected citations for BRL 37344, sodium salt include:

Rankovic et al (2011) Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One 6 e27474 PMID: 22164209

Brahmadevara et al (2004) ALpha1-adrenoceptor antagonist properties of CGP 12177A and other beta-adrenoceptor ligands: evidence against beta(3)- or atypical beta-adrenoceptors in rat aorta. Br J Pharmacol 142 781 PMID: 15205310

Cirino et al (2003) Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. J Biol Chem 100 5531 PMID: 12707413

Steinle et al (2003) β 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation. J Pharmacol Exp Ther 278 20681 PMID: 12670949

Do you know of a great paper that uses BRL 37344, sodium salt from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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