BRL 37344, sodium salt

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Cat.No. 0948 - BRL 37344, sodium salt | C19H21NO4ClNa | CAS No. 127299-93-8
Description: β3 agonist
Chemical Name: (R*,R*)-(±)-4-[2-[(2-(3-Chlorophenyl)-2-hydroxyethyl)amino]propyl]phenoxyacetic acid, sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Literature

Biological Activity

Potent and selective β3 adrenoceptor agonist (Ki values are 287, 1750 and 1120 nM for β3, β1 and β2 receptors respectively). Also available as part of the β-Adrenoceptor Agonist Tocriset™.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M. Wt 385.82
Formula C19H21NO4ClNa
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 127299-93-8
PubChem ID 16219010
InChI Key SNJIJYKMYQRHRC-WJKBNZMCSA-M
Smiles [Na+].C[C@H](CC1=CC=C(OCC([O-])=O)C=C1)NC[C@H](O)C1=CC(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 38.58 100

Preparing Stock Solutions

The following data is based on the product molecular weight 385.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.96 mL 25.92 mL
5 mM 0.52 mL 2.59 mL 5.18 mL
10 mM 0.26 mL 1.3 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Arch et al (1984) Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 309 163 PMID: 6325935

Ayo Oriowo et al (1996) The selectivity in vitro of the sterioisomers of the beta-3 adrenoreceptor agonist BRL 37344. J.Pharmacol.Exp.Ther. 277 22 PMID: 8613923

Board et al (2000) BRL37344, but not CGP12177, stimulates fuel oxidation by soleus muscle in vitro. Eur.J.Pharmacol. 406 33 PMID: 11011029

Strosberg and Pietri-Rouxel (1996) Function and regulation of the β3-adrenoceptor. TiPS 17 373 PMID: 8979772


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8 Citations for BRL 37344, sodium salt

Citations are publications that use Tocris products. Selected citations for BRL 37344, sodium salt include:

Rankovic et al (2011) Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One 6 e27474 PMID: 22164209

Maupoil et al (2007) Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol 150 899 PMID: 17325650

Cirino et al (2003) Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. J Biol Chem 100 5531 PMID: 12707413

Steinle et al (2003) β 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation. J Pharmacol Exp Ther 278 20681 PMID: 12670949

Lavine (2017) β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression. Invest Ophthalmol Vis Sci 58 299 PMID: 28114591

Littmann et al (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. Dev Neurosci 355 183 PMID: 26306764

Suárez et al (2014) Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech 7 129 PMID: 24159189

Lavine et al (2013) Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism. JAMA Ophthalmol 131 376 PMID: 23303344


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