Adenosine A1 Receptors

The A1 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A2A, A2B and A3. A1 receptors display high expression levels in the brain (cortex, cerebellum, hippocampus), dorsal horn of the spinal cord, eye and atria.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1705 2-Chloro-N6-cyclopentyladenosine
Potent, selective A1 agonist
1702 N6-Cyclopentyladenosine
Potent, selective A1 agonist
5122 Dansyl-NECA
Potent and selective fluorescent adenosine A1 agonist
3576 (±)-5'-Chloro-5'-deoxy-ENBA
Highly selective A1 agonist
1957 GR 79236
A1 agonist
2281 2'-MeCCPA
Very selective and potent A1 receptor agonist
2465 SDZ WAG 994
Potent, selective A1 agonist

Antagonists

Cat No Product Name / Activity
6137 8-Cyclopentyl-1,3-dimethylxanthine
High affinity adenosine A1 receptor antagonist
0486 1,3-Dipropyl-8-phenylxanthine
A1 selective antagonist
0439 DPCPX
A1 selective antagonist
4167 KW 3902
Selective A1 antagonist
5351 PQ 69
Potent and selective A1 antagonist/inverse agonist
2019 PSB 36
Potent and selective A1 antagonist
3344 SLV 320
Potent and selective A1 antagonist

Modulators

Cat No Product Name / Activity
1363 PD 81723
Allosteric potentiator of A1 receptors

The A1 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A2A, A2B and A3. A1 receptors display high expression levels in the brain (cortex, cerebellum, hippocampus), dorsal horn of the spinal cord, eye, adrenal gland and atria. Lower expression levels are also found in the liver, kidney, skeletal muscle, adipose tissue, colon, testes, salivary glands and oesophagus. A1 receptors play a role in lipolysis, antinociception and cardio- and neuroprotection. The human A1 receptor gene is localized on chromosome 1 (1q32.1)

External sources of pharmacological information for Adenosine A1 Receptors :

Literature for Adenosine A1 Receptors

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Adenosine A1 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human ADORA1 NM_000674 P30542
Mouse Adora1 NM_001008533 Q60612
Rat Adora1 NM_017155 P25099