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Adenosine A1 Receptors

The A1 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A2A, A2B and A3. A1 receptors display high expression levels in the brain (cortex, cerebellum, hippocampus), dorsal horn of the spinal cord, eye and atria.

Products
Background
Literature (4)
Gene Data

Adenosine A1 Receptor Agonists
Cat. No. Product Name / Activity
1705 2-Chloro-N6-cyclopentyladenosine
Potent and selective A1 agonist
1702 N6-Cyclopentyladenosine
Potent and selective A1 agonist
3576 (±)-5'-Chloro-5'-deoxy-ENBA
Highly selective A1 agonist
2281 2'-MeCCPA
Highly selective and potent A1 receptor agonist
6863 N6-Cyclohexyladenosine
High affinity A1 receptor agonist
2465 SDZ WAG 994
Potent and selective A1 agonist

Adenosine A1 Receptor Antagonists
Cat. No. Product Name / Activity
6137 8-Cyclopentyl-1,3-dimethylxanthine
High affinity adenosine A1 receptor antagonist
0439 DPCPX
Selective A1 antagonist
4167 KW 3902
Selective A1 antagonist

Adenosine A1 Receptor Modulators
Cat. No. Product Name / Activity
1363 PD 81723
Positive allosteric modulator of A1 receptors
6261 VCP 171
Positive allosteric modulator (PAM) of A1 receptors; also allosteric partial agonist in absence of orthosteric agonist

Related Targets

The A1 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A2A, A2B and A3. A1 receptors display high expression levels in the brain (cortex, cerebellum, hippocampus), dorsal horn of the spinal cord, eye, adrenal gland and atria. Lower expression levels are also found in the liver, kidney, skeletal muscle, adipose tissue, colon, testes, salivary glands and oesophagus. A1 receptors play a role in lipolysis, antinociception and cardio- and neuroprotection. The human A1 receptor gene is localized on chromosome 1 (1q32.1)

External sources of pharmacological information for Adenosine A1 Receptors :

Literature for Adenosine A1 Receptors

Tocris offers the following scientific literature for Adenosine A1 Receptors to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

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GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
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Pain Research Product Guide

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
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Cardiovascular Poster

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Adenosine A1 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human ADORA1 NM_000674 P30542
Mouse Adora1 NM_001008533 Q60612
Rat Adora1 NM_017155 P25099