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SDZ WAG 994
Biological Activity for SDZ WAG 994
SDZ WAG 994 is a potent and selective A1 adenosine receptor agonist (Ki values are 23, > 10000 and 25000 nM for A1, A2A and A2B receptors respectively). Causes a sustained fall in blood pressure and heart rate in spontaneous hypertensive rats and inhibits adenosine deaminase-stimulated lipolysis in rat adipocytes (Ki = 8 nM).
Compound Libraries for SDZ WAG 994
Technical Data for SDZ WAG 994
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SDZ WAG 994
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SDZ WAG 994
The following data is based on the product molecular weight 363.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.75 mL||13.76 mL||27.52 mL|
|5 mM||0.55 mL||2.75 mL||5.5 mL|
|10 mM||0.28 mL||1.38 mL||2.75 mL|
|50 mM||0.06 mL||0.28 mL||0.55 mL|
References for SDZ WAG 994
References are publications that support the biological activity of the product.
Ishikawa et al (1998) Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneous hypertensive rat complicated with hyperglycemia. Diabetes Res.Clin.Pract. 39 3 PMID: 9597368
Jacobson and Gao (2006) Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 5 247 PMID: 16518376
Wagner et al (1995) General pharmacology of SDZ WAG 994, a potent selective and orally active adenosine A1 receptor agonist. Drug Dev.Res. 34 276
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Keywords: SDZ WAG 994, SDZ WAG 994 supplier, Potent, selective, A1, agonists, Receptors, adenosines, SDZWAG994, Adenosine, 2465, Tocris Bioscience
Citations for SDZ WAG 994
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Literature in this Area
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