SDZ WAG 994

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Cat.No. 2465 - SDZ WAG 994 | C17H25N5O4 | CAS No. 130714-47-5
Description: Potent, selective A1 agonist
Chemical Name: N-Cyclohexyl-2'-O-methyladenosine
Purity: ≥99% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

Potent and selective A1 adenosine receptor agonist (Ki values are 23, > 10000 and 25000 nM for A1, A2A and A2B receptors respectively). Causes a sustained fall in blood pressure and heart rate in spontaneous hypertensive rats and inhibits adenosine deaminase-stimulated lipolysis in rat adipocytes (Ki = 8 nM).

Compound Libraries

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Technical Data

M. Wt 363.41
Formula C17H25N5O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 130714-47-5
PubChem ID 164305
InChI Key JAKAFSGZUXCHLF-LSCFUAHRSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N(C=N4)C2=C4C(NC3CCCCC3)=NC=N2)[C@@H]1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 36.34 100
DMSO 36.34 100
ethanol 36.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 363.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.76 mL 27.52 mL
5 mM 0.55 mL 2.75 mL 5.5 mL
10 mM 0.28 mL 1.38 mL 2.75 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ishikawa et al (1998) Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneous hypertensive rat complicated with hyperglycemia. Diabetes Res.Clin.Pract. 39 3 PMID: 9597368

Jacobson and Gao (2006) Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 5 247 PMID: 16518376

Wagner et al (1995) General pharmacology of SDZ WAG 994, a potent selective and orally active adenosine A1 receptor agonist. Drug Dev.Res. 34 276 PMID:


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