Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPD 81723
Description: Positive allosteric modulator of A1 receptors
Chemical Name: (2-Amino-4,5-dimethyl-3-thienyl)-[3-(trifluoromethyl)phenyl]methanone
Purity: ≥99% (HPLC)
Biological Activity for PD 81723
PD 81723 is an allosteric potentiator at the adenosine A1 receptor; acts via agonist-dependent and -independent mechanisms. Enhances agonist affinity for, and increased t½ of dissociation from, the receptor. Also inhibits basal and forskolin-stimulated adenylyl cyclase (AC) activity in A1 receptors expressed in CHO cells, possibly via direct potentiation of constitutive receptor activity or by direct inhibition of AC. Active in vivo.
Technical Data for PD 81723
| M. Wt | 299.31 |
| Formula | C14H12F3NOS |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 132861-87-1 |
| PubChem ID | 122028 |
| InChI Key | KKDKAWKYGCUOGR-UHFFFAOYSA-N |
| Smiles | CC1=C(C)C(C(=O)C2=CC(=CC=C2)C(F)(F)F)=C(N)S1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PD 81723
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 29.93 | 100 | |
| DMSO | 29.93 | 100 |
Preparing Stock Solutions for PD 81723
The following data is based on the product molecular weight 299.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.34 mL | 16.71 mL | 33.41 mL |
| 5 mM | 0.67 mL | 3.34 mL | 6.68 mL |
| 10 mM | 0.33 mL | 1.67 mL | 3.34 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for PD 81723
References for PD 81723
References are publications that support the biological activity of the product.
Bruns et al (1990) Structure-activity relationships for enhancement of adenosine A1 receptor binding by 2-amino-3-benzoylthiophenes. Mol.Pharmacol. 38 950 PMID: 2250667
Kollias-Baker et al (1997) Agonist-independent effect of an allosteric enhancer of the A1 adenosine receptor in CHO cells stably expressing the recombinant human A1 receptor. J.Pharmacol.Exp.Ther. 281 761 PMID: 9152383
Mizumura et al (1996) PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogs. Circ.Res. 79 415 PMID: 8781475
Musser et al (1999) Adenosine A1 receptor-dependent and -independent effects of the allosteric enhancer PD 81,723. J.Pharmacol.Exp.Ther. 288 446 PMID: 9918544
If you know of a relevant reference for PD 81723, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PD 81723, PD 81723 supplier, Allosteric, potentiators, A1, receptors, Receptors, adenosines, PD81723, Adenosine, 1363, Tocris Bioscience
Citations for PD 81723
Citations are publications that use Tocris products.
Currently there are no citations for PD 81723. Do you know of a great paper that uses PD 81723 from Tocris? Please let us know.
Reviews for PD 81723
There are currently no reviews for this product. Be the first to review PD 81723 and earn rewards!
Have you used PD 81723?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image