PD 81723

Pricing Availability   Qty
Description: Positive allosteric modulator of A1 receptors
Chemical Name: (2-Amino-4,5-dimethyl-3-thienyl)-[3-(trifluoromethyl)phenyl]methanone
Purity: ≥99% (HPLC)

Biological Activity for PD 81723

PD 81723 is an allosteric potentiator at the adenosine A1 receptor; acts via agonist-dependent and -independent mechanisms. Enhances agonist affinity for, and increased t½ of dissociation from, the receptor. Also inhibits basal and forskolin-stimulated adenylyl cyclase (AC) activity in A1 receptors expressed in CHO cells, possibly via direct potentiation of constitutive receptor activity or by direct inhibition of AC. Active in vivo.

Technical Data for PD 81723

M. Wt 299.31
Formula C14H12F3NOS
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 132861-87-1
PubChem ID 122028
Smiles CC1=C(C)C(C(=O)C2=CC(=CC=C2)C(F)(F)F)=C(N)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PD 81723

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 29.93 100
DMSO 29.93 100

Preparing Stock Solutions for PD 81723

The following data is based on the product molecular weight 299.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.34 mL 16.71 mL 33.41 mL
5 mM 0.67 mL 3.34 mL 6.68 mL
10 mM 0.33 mL 1.67 mL 3.34 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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Product Datasheets for PD 81723

Certificate of Analysis / Product Datasheet
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References for PD 81723

References are publications that support the biological activity of the product.

Bruns et al (1990) Structure-activity relationships for enhancement of adenosine A1 receptor binding by 2-amino-3-benzoylthiophenes. Mol.Pharmacol. 38 950 PMID: 2250667

Kollias-Baker et al (1997) Agonist-independent effect of an allosteric enhancer of the A1 adenosine receptor in CHO cells stably expressing the recombinant human A1 receptor. J.Pharmacol.Exp.Ther. 281 761 PMID: 9152383

Mizumura et al (1996) PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogs. Circ.Res. 79 415 PMID: 8781475

Musser et al (1999) Adenosine A1 receptor-dependent and -independent effects of the allosteric enhancer PD 81,723. J.Pharmacol.Exp.Ther. 288 446 PMID: 9918544

If you know of a relevant reference for PD 81723, please let us know.

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Keywords: PD 81723, PD 81723 supplier, Allosteric, potentiators, A1, receptors, Receptors, adenosines, PD81723, Adenosine, 1363, Tocris Bioscience

Citations for PD 81723

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