Adenosine A2B Receptors

Adenosine A2B receptors are members of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2A and A3. A2B receptors display high expression levels in the cecum, colon and bladder, with lower levels in the lung, blood vessels and eye.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
4472 BAY 60-6583
Potent A2B receptor agonist; cardioprotective
1710 CV 1808
Non-selective adenosine A2 receptor agonist
4603 LUF 5834
Potent adenosine A2A and A2B receptor partial agonist

Antagonists

Cat No Product Name / Activity
4727 GS 6201
Selective A2B antagonist
5965 ISAM 140
High affinity A2B receptor antagonist
1584 MRS 1706
Potent and selective A2B inverse agonist
2752 MRS 1754
Selective A2B antagonist
3199 PSB 0788
Selective A2B antagonist
2009 PSB 1115
Selective human A2B receptor antagonist; water-soluble
3198 PSB 603
Highly selective A2B antagonist

Adenosine A2B receptors are members of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2A and A3. A2B receptors display high expression levels in the cecum, colon and bladder, with lower levels found in the lung, blood vessels, eye, median eminence and mast cells. A2B receptors play a role in the relaxation of smooth muscle in the vasculature and intestines, inhibit monocyte and macrophage function and stimulate mast cell mediator release. The human A2B receptor gene is localized on chromosome 17 (17p12-p11.2).

Both A2A and A2B receptors are important in cancer immunology. The tumor microenvironment is hypoxic, which promotes the expression of CD39 and CD73 by immune cells. CD39 and CD73 are ectonucleotidases that convert ATP to adenosine, elevating concentrations of adenosine locally. Adenosine is a crucial mediator of altered immune function in cancer as it binds A2A and A2B receptors on lymphocytes silencing the antitumor immune response.

External sources of pharmacological information for Adenosine A2B Receptors :

Literature for Adenosine A2B Receptors

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Adenosine A2B Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human ADORA2B NM_000675 P29274
Mouse Adora2b NM_009630 Q60613
Rat Adora2b NM_053294 P30543