KW 3902

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Cat.No. 4167 - KW 3902 | C20H28N4O2 | CAS No. 136199-02-5
Description: Selective A1 antagonist
Alternative Names: Rolofylline
Chemical Name: 8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective adenosine A1 receptor antagonist; displays 890-fold selectivity for rat A1 receptors over A2A receptors (Ki values are 0.19 and 170 nM respectively). Displays no effect on recombinant rat A3 receptors expressed on CHO cells at concentrations up to 10 μM. Exhibits diuretic and renal protective effects in rats.

Compound Libraries

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Technical Data

M. Wt 356.46
Formula C20H28N4O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 136199-02-5
PubChem ID 64627
InChI Key PJBFVWGQFLYWCB-UHFFFAOYSA-N
Smiles O=C1C2=C(NC(C34CC(CC4C5)CC5C3)=N2)N(CCC)C(N1CCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.82 50
ethanol 8.91 25

Preparing Stock Solutions

The following data is based on the product molecular weight 356.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.03 mL 28.05 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
10 mM 0.28 mL 1.4 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Shimada et al (1992) 8-polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors. J.Med.Chem. 35 924 PMID: 1548682

Nonaka et al (1996) KW-3902, a selective high affinity antagonist for adenosine A1 receptors. Br.J.Pharmacol. 117 1645 PMID: 8732272

Nishiyama et al (1999) Adenosine A1 receptor antagonist KW-3902 prevents hypoxia-induced renal vasoconstriction. J.Pharmacol.Exp.Ther. 291 988 PMID: 10565815


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Keywords: KW 3902, supplier, adenosine, a1, antagonists, selective, KW3902, Rolofylline, Adenosine, A1, Receptors, Tocris Bioscience

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