(±)-5'-Chloro-5'-deoxy-ENBA

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Cat.No. 3576 - (±)-5'-Chloro-5'-deoxy-ENBA | C17H22ClN5O3 | CAS No. 103626-26-2
Description: Highly selective A1 agonist
Chemical Name: N-Bicyclo[2.2.1]hept-2-yl-5'-chloro-5'-deoxyadenosine
Purity: ≥98% (HPLC)
Datasheet
Citations

Biological Activity

Highly selective adenosine A1 receptor agonist (Ki values are 0.51, 1290, 1340 and 2740 nM at A1, A3, A2A and A2B receptors respectively). Reverses formaline-induced nocifensive behavior in mice; antinociceptive.

Compound Libraries

(±)-5'-Chloro-5'-deoxy-ENBA is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 379.84
Formula C17H22ClN5O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 103626-26-2
PubChem ID 42636897
InChI Key PVJGDYDNVNCGBT-STHLEMNDSA-N
Smiles O[C@@H]1[C@H](O)[C@@H](CCl)O[C@H]1N(C=N3)C2=C3C(NC4C5CCC(C5)C4)=NC=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.98 100
ethanol 37.98 100

Preparing Stock Solutions

The following data is based on the product molecular weight 379.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.16 mL 26.33 mL
5 mM 0.53 mL 2.63 mL 5.27 mL
10 mM 0.26 mL 1.32 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Trivedi et al (1989) N6-bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor. J.Med.Chem. 32 8 PMID: 2909748

Franchetti et al (2009) N6-cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice. J.Med.Chem. 52 2393 PMID: 19317449


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Keywords: highly selective A1 adenosines receptors agonists (±)-5-Chloro-5-deoxy-ENBA ENBA Adenosine A1 Receptors

Citations for (±)-5'-Chloro-5'-deoxy-ENBA

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