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Submit Review8-Cyclopentyl-1,3-dimethylxanthine
Description: High affinity adenosine A1 receptor antagonist
Alternative Names: CPT, 8-Cyclopentyltheophylline
Chemical Name: 8-Cyclopentyltheophylline
Purity: ≥99% (HPLC)
Biological Activity for 8-Cyclopentyl-1,3-dimethylxanthine
8-Cyclopentyl-1,3-dimethylxanthine is a high affinity adenosine A1 receptor antagonist (pKi = 7.5-8).
Compound Libraries for 8-Cyclopentyl-1,3-dimethylxanthine
8-Cyclopentyl-1,3-dimethylxanthine is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for 8-Cyclopentyl-1,3-dimethylxanthine
| M. Wt | 248.28 |
| Formula | C12H16N4O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 35873-49-5 |
| PubChem ID | 1917 |
| InChI Key | SCVHFRLUNIOSGI-UHFFFAOYSA-N |
| Smiles | CN1C2=C(C(N(C1=O)C)=O)N=C(C3CCCC3)N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 8-Cyclopentyl-1,3-dimethylxanthine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.83 | 100 | |
| ethanol | 2.48 | 10 |
Preparing Stock Solutions for 8-Cyclopentyl-1,3-dimethylxanthine
The following data is based on the product molecular weight 248.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.03 mL | 20.14 mL | 40.28 mL |
| 5 mM | 0.81 mL | 4.03 mL | 8.06 mL |
| 10 mM | 0.4 mL | 2.01 mL | 4.03 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.81 mL |
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Product Datasheets for 8-Cyclopentyl-1,3-dimethylxanthine
References for 8-Cyclopentyl-1,3-dimethylxanthine
References are publications that support the biological activity of the product.
Dalpiaz et al (1998) Thermodynamics of full agonist, partial agonist, and antagonist binding to wild-type and mutant adenosine A1 receptors. Biochem.Pharmacol. 56 1437 PMID: 9827575
If you know of a relevant reference for 8-Cyclopentyl-1,3-dimethylxanthine, please let us know.
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Keywords: 8-Cyclopentyl-1,3-dimethylxanthine, 8-Cyclopentyl-1,3-dimethylxanthine supplier, Adenosine, A1, receptors, antagonists, antagonism, high, affinity, CPT, 8-Cyclopentyltheophylline, Receptors, 6137, Tocris Bioscience
Citations for 8-Cyclopentyl-1,3-dimethylxanthine
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