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Adenosine A3 Receptors

The adenosine A3 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2A and A2B. They display high expression levels in the testes and mast cells of rats, with low expression levels in the thyroid, liver, kidney and heart.

Products
Background
Literature
Gene Data

Agonists
Cat No Product Name / Activity
1104 2-Cl-IB-MECA
Highly selective A3 agonist
1579 HEMADO
High affinity selective A3 agonist
1066 IB-MECA
A3 selective agonist
5428 MRS 5698
High affinity and selective A3 adenosine receptor agonist

Antagonists
Cat No Product Name / Activity
4041 MRE 3008F20
Highly potent and selective adenosine A3 receptor antagonist
1217 MRS 1220
Highly potent, selective hA3 antagonist
1385 MRS 1334
Potent, highly selective hA3 antagonist
2403 MRS 3777 hemioxalate
High affinity, selective A3 antagonist
2010 PSB 10 hydrochloride
Potent, highly selective hA3 receptor antagonist/inverse agonist
2012 PSB 11 hydrochloride
Potent, selective hA3 receptor antagonist/inverse agonist
1359 VUF 5574
Potent, selective hA3 antagonist

Related Targets

The adenosine A3 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2A and A2B. They display high expression levels in the testes and mast cells of rats, with low expression levels in the thyroid, liver, kidney, heart, intestine and most brain areas. Adenosine A3 receptors play a role in mast cell degranulation, coronary vasodilation and protection from reperfusion. The human A3 receptor gene is localized on chromosome 1 (1p21-p13).

External sources of pharmacological information for Adenosine A3 Receptors :

Literature for Adenosine A3 Receptors

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
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GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
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  • Frizzled Receptors
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Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
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Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Adenosine A3 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human ADORA3 NM_000677 P33765
Mouse Adora3 NM_027025 Q61618
Rat Adora3 NM_012896 P28647