Adenosine A3 Receptors
The adenosine A3 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2A and A2B. They display high expression levels in the testes and mast cells of rats, with low expression levels in the thyroid, liver, kidney and heart.
Agonists |
|
|---|---|
| Cat No | Product Name / Activity |
| 1104 | 2-Cl-IB-MECA |
| Highly selective A3 agonist | |
| 1579 | HEMADO |
| High affinity selective A3 agonist | |
| 1066 | IB-MECA |
| A3 selective agonist | |
| 5428 | MRS 5698 |
| High affinity and selective A3 adenosine receptor agonist | |
Antagonists |
|
| Cat No | Product Name / Activity |
| 4041 | MRE 3008F20 |
| Highly potent and selective adenosine A3 receptor antagonist | |
| 1217 | MRS 1220 |
| Highly potent, selective hA3 antagonist | |
| 1385 | MRS 1334 |
| Potent, highly selective hA3 antagonist | |
| 2403 | MRS 3777 hemioxalate |
| High affinity, selective A3 antagonist | |
| 2010 | PSB 10 hydrochloride |
| Potent, highly selective hA3 receptor antagonist/inverse agonist | |
| 2012 | PSB 11 hydrochloride |
| Potent, selective hA3 receptor antagonist/inverse agonist | |
| 1359 | VUF 5574 |
| Potent, selective hA3 antagonist | |
The adenosine A3 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A1, A2A and A2B. They display high expression levels in the testes and mast cells of rats, with low expression levels in the thyroid, liver, kidney, heart, intestine and most brain areas. Adenosine A3 receptors play a role in mast cell degranulation, coronary vasodilation and protection from reperfusion. The human A3 receptor gene is localized on chromosome 1 (1p21-p13).
External sources of pharmacological information for Adenosine A3 Receptors :
Literature for Adenosine A3 Receptors
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Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity.
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