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Potent and highly selective agonist at A1 adenosine receptors (Ki values are 3.3, 9580, 37600 and 1150 nM for human recombinant A1, A2A, A2B and A3 receptors respectively). Acts as a full agonist; inhibits forskolin-stimulated adenylyl cyclase activity in rat cortical membranes with an IC50 value of 13.1 nM.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 383.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||10.42 mL||52.11 mL||104.21 mL|
|1.25 mM||2.08 mL||10.42 mL||20.84 mL|
|2.5 mM||1.04 mL||5.21 mL||10.42 mL|
|12.5 mM||0.21 mL||1.04 mL||2.08 mL|
References are publications that support the biological activity of the product.
Franchetti et al (1998) 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. J.Med.Chem. 41 1708 PMID: 9572897
Cappellacci et al (2005) Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. J.Med.Chem. 48 1550 PMID: 15743197
If you know of a relevant reference for 2'-MeCCPA, please let us know.
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Keywords: 2'-MeCCPA, 2'-MeCCPA supplier, selective, potent, A1, receptor, agonists, Receptors, adenosines, 2-MeCCPA, Adenosine, 2281, Tocris Bioscience
2 Citations for 2'-MeCCPA
Citations are publications that use Tocris products. Selected citations for 2'-MeCCPA include:
Liu et al (2018) Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect. Brain Res 1700 47 PMID: 29935155
Yang et al (2010) Adenosine mediated desensitization of cAMP signaling enhances T-cell responses. Eur J Immunol 40 449 PMID: 19950175
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