Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review2'-MeCCPA
Description: Highly selective and potent A1 receptor agonist
Chemical Name: 2-Chloro-N-cyclopentyl-2'-methyladenosine
Purity: ≥98% (HPLC)
Biological Activity for 2'-MeCCPA
2'-MeCCPA is a potent and highly selective agonist at A1 adenosine receptors (Ki values are 3.3, 9580, 37600 and 1150 nM for human recombinant A1, A2A, A2B and A3 receptors respectively). Acts as a full agonist; inhibits forskolin-stimulated adenylyl cyclase activity in rat cortical membranes with an IC50 value of 13.1 nM.
Compound Libraries for 2'-MeCCPA
2'-MeCCPA is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for 2'-MeCCPA
| M. Wt | 383.83 |
| Formula | C16H22ClN5O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 205171-12-6 |
| PubChem ID | 10475082 |
| InChI Key | MMPAUXMIDJWGFO-ROMFRFKVSA-N |
| Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC3=C2N=C(Cl)N=C3NC4CCCC4)[C@@](C)1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 2'-MeCCPA
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.6 | 25 |
Preparing Stock Solutions for 2'-MeCCPA
The following data is based on the product molecular weight 383.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 10.42 mL | 52.11 mL | 104.21 mL |
| 1.25 mM | 2.08 mL | 10.42 mL | 20.84 mL |
| 2.5 mM | 1.04 mL | 5.21 mL | 10.42 mL |
| 12.5 mM | 0.21 mL | 1.04 mL | 2.08 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for 2'-MeCCPA
References for 2'-MeCCPA
References are publications that support the biological activity of the product.
Franchetti et al (1998) 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. J.Med.Chem. 41 1708 PMID: 9572897
Cappellacci et al (2005) Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. J.Med.Chem. 48 1550 PMID: 15743197
If you know of a relevant reference for 2'-MeCCPA, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 2'-MeCCPA, 2'-MeCCPA supplier, selective, potent, A1, receptor, agonists, Receptors, adenosines, 2-MeCCPA, Adenosine, 2281, Tocris Bioscience
2 Citations for 2'-MeCCPA
Citations are publications that use Tocris products. Selected citations for 2'-MeCCPA include:
Yang et al (2010) Adenosine mediated desensitization of cAMP signaling enhances T-cell responses. Eur J Immunol 40 449 PMID: 19950175
Liu et al (2018) Adenosine binds predominantly to adenosine receptor A1 subtype in astrocytes and mediates an immunosuppressive effect. Brain Res 1700 47 PMID: 29935155
Do you know of a great paper that uses 2'-MeCCPA from Tocris? Please let us know.
Reviews for 2'-MeCCPA
There are currently no reviews for this product. Be the first to review 2'-MeCCPA and earn rewards!
Have you used 2'-MeCCPA?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cardiovascular Research Product Guide
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Hypertension
- Thrombosis and Hemostasis
- Atherosclerosis
- Myocardial Infarction
- Ischemia/Reperfusion Injury
- Arrhythmias
- Heart Failure
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
Pain Research Product Guide
A collection of over 280 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Cardiovascular Poster
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.