2'-MeCCPA

Pricing Availability Delivery Time Qty
Cat.No. 2281 - 2'-MeCCPA | C16H22ClN5O4 | CAS No. 205171-12-6
Description: Very selective and potent A1 receptor agonist
Chemical Name: 2-Chloro-N-cyclopentyl-2'-methyladenosine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and highly selective agonist at A1 adenosine receptors (Ki values are 3.3, 9580, 37600 and 1150 nM for human recombinant A1, A2A, A2B and A3 receptors respectively). Acts as a full agonist; inhibits forskolin-stimulated adenylyl cyclase activity in rat cortical membranes with an IC50 value of 13.1 nM.

Compound Libraries

2'-MeCCPA is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 383.83
Formula C16H22ClN5O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 205171-12-6
PubChem ID 10475082
InChI Key MMPAUXMIDJWGFO-ROMFRFKVSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC3=C2N=C(Cl)N=C3NC4CCCC4)[C@@](C)1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.6 25

Preparing Stock Solutions

The following data is based on the product molecular weight 383.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.03 mL 26.05 mL
5 mM 0.52 mL 2.61 mL 5.21 mL
10 mM 0.26 mL 1.3 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Franchetti et al (1998) 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. J.Med.Chem. 41 1708 PMID: 9572897

Cappellacci et al (2005) Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. J.Med.Chem. 48 1550 PMID: 15743197


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Keywords: 2'-MeCCPA, supplier, selective, potent, A1, receptor, agonists, Receptors, adenosines, 2-MeCCPA, Adenosine, A1, Receptors, Adenosine, A1, Receptors, Tocris Bioscience

Citations for 2'-MeCCPA

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