Stem Cell Differentiation

More Information »Stem cell differentiation involves the changing of a cell to a more specialized cell type, involving a switch from proliferation to specialization. This involves a succession of alterations in cell morphometry, membrane potential, metabolic activity and signal responsiveness.

Stem Cell Differentiation Products

Product Name / Activity
4845 A 939572
SCD1 inhibitor; induces cell death of undifferentiated human ESCs
2840 AICAR
AMPK activator; promotes osteogenic differentiation of bone marrow-derived MSCs
3842 5-Azacytidine
DNA methyltransferase inhibitor; induces differentiation of MSCs into cardiomyocytes
5819 Bexarotene
Potent and selective RXR agonist; promotes brown adipogenic differentiation
6047 BOP
Preferentially mobilizes HSCs; also a dual α9β/1α4β1 integrin
3851 Cardiogenol C hydrochloride
Induces cardiomyocyte differentiation in ESCs
4475 Cardionogen 1
Inhibitor of Wnt/β-catenin signaling; induces ES cell cardiac differentiation
5233 CCG 1423
Induces intermediate mesoderm differentiation from ESCs; Rho/SRF pathway inhibitor
3858 CH 223191
AhR antagonist; attenuates Th17 differentiation of naive CD4 T cells
5329 CKI 7 dihydrochloride
CK1 inhibitor; induces retinal cell differentiation from human ESCs and iPSCs
5495 CW 008
Promotes osteogenic differentiation of hMSCs; cAMP/PKA/CREB pathway activator
1623 Cyclopamine
Inhibitor of Hedgehog (Hh) signaling; induces differentiation of hESCs into hormone expressing endocrine cells
2634 DAPT
γ-secretase inhibitor; induces neuronal differentiation
1126 Dexamethasone
Anti-inflammatory glucocorticoid; induces differentiation of human MSCs
5566 DG 172 dihydrochloride
Promotes bone marrow cell differentiation; also PPARβ/δ inverse agonist
1141 Dibutyryl-cAMP, sodium salt
Promotes differentiation of hPSCs to dopaminergic neurons; cell-permeable cAMP analog
4126 DMH-1
BMP receptor ALK2 inhibitor; promotes iPSC neurogenesis in combination with SB 431542 (Cat. No. 1614)
3176 DMSO, sterile filtered
Improves responsiveness of hESCs and hiPSCs to differentiation signals
3093 Dorsomorphin dihydrochloride
BMP type I receptor (ALK2, ALK3 and ALK6) inhibitor; promotes cardiomyocyte differentiation in mouse ESCs
1041 1-EBIO
KCa activator; promotes ESC differentiation into cardiomyocytes
5849 EC 19
Synthetic retinoid; induces differentiation of stem cells
4011 EC 23
Synthetic retinoid; induces neural differentiation of hESCs
5254 FH 1
Enhances iPSC-derived hepatocyte differentiation and maturation
0927 Fluoxetine hydrochloride
5-HT re-uptake inhibitor; induces differentiation of neuronal precursors
1099 Forskolin
Adenylyl cyclase activator; induces neuronal differentiation
4918 GSA 10
Smo receptor agonist; induces differentiation of mesenchymal progenitor cells into osteoblasts
3912 HX 531
Potent RXR antagonist; promotes white adipocyte differentiation
4650 I-BET 151 dihydrochloride
Promotes differentiation of hiPSCs into megakaryocytes; also BET bromodomain inhibitor
2845 IBMX
PDE inhibitor; facilitates differentiation of neural progenitor cells
4015 IDE 1
Induces definitive endoderm formation in mouse and human ESCs
4016 IDE 2
Induces definitive endoderm formation in mouse and human ESCs
5513 Isotretinoin
Inducer of neuronal differentiation; endogenous agonist for retinoic acid receptors
4439 ISX 9
Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation
5068 ITD 1
Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs
1803 ITE
Induces stem-like cancer cell differentiation; also inhibits TGF-β-induced human myofibroblast differentiation
5214 IWP 4
Potent inhibitor of Wnt/β-catenin signaling; induces cardiomyocyte differentiation of human ESCs and iPSCs
4513 Kartogenin
Potently induces chondrogenesis in MSCs
4888 KHS 101 hydrochloride
Selective inducer of neuronal differentiation in hippocampal neural progenitors
4731 KY 02111
Inhibits canonical Wnt signaling. Promotes differentiation of human ESCs and iPSCs into cardiomyocytes
6053 LDN 193189 dihydrochloride
Induces neural induction of hPSCs in combination with SB 431542 (Cat. No. 1614)
6068 Lin28 1632
RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor
5552 Liothyronine sodium
Promotes adipogenic differentiation of MSCs; also thyroid hormone (T3) analog
2864 Metformin hydrochloride
Activator of LKB1/AMPK; enhances neurogenesis
5186 Neuropathiazol
Selective inducer of neuronal differentiation in hippocampal neural progenitors
4106 Nicotinamide
Promotes MSC differentiation; anti-inflammatory agent
3854 1-Oleoyl lysophosphatidic acid sodium salt
LPA1 and LPA2 agonist; inhibits differentiation of neural stem cells into neurons
4076 P7C3
Neuroprotective compound; enhances neurogenesis in vivo
3044 PD 173074
Selective FGFR1 and -3 inhibitor; inhibits proliferation and differentiation of oligodendrocyte progenitors
5778 2-Phospho-L-ascorbic acid trisodium salt
Ascorbic acid derivative; maintains differentiation potential in bone marrow-derived MSCs
0238 O-Phospho-L-serine
Group III mGlu agonist; enhances differentiation of neural progenitor cells
4847 PluriSln 1
Inhibitor of SCD1; selectively eliminates undifferentiated hPSCs from culture
4551 Purmorphamine
Smo receptor agonist; induces differentiation of mesenchymal progenitor cells into osteoblasts
1292 Rapamycin
mTOR inhibitor; also drives hPSC differentiation to mesendoderm and blood progenitor cells
0695 Retinoic acid
Endogenous retinoic acid receptor agonist; promotes ESC differentiation
5325 Rosiglitazone
Promotes differentiation of adipocytes; also potent and selective PPARγ agonist
4366 SAG
Enhances neuronal differentiation of iPSCs into dopaminergic neurons; Smo agonist
1614 SB 431542
Promotes stem cell proliferation, differentiation and sheet formation
4923 Shz 1
Activator of early cardiac genes in pluripotent stem cells; induces differentiation in M-PBMCs
5291 SIS3
Selective Smad3 inhibitor; inhibits TGF-β-induced myofibroblast differentiation
3850 Sodium butyrate
Histone deacetylase inhibitor; directs differentiation of mESCs into hepatocytes
1496 SP 600125
JNK inhibitor; prevents BMP9-induced osteogenic differentiation of MSCs
3741 Stauprimide
Inhibits NME2 nuclear translocation; primes ESCs for differentiation
4484 STF 31
Eliminates undifferentiated hPSCs from culture; also NAMPT and GLUT1 inhibitor
4749 Strontium chloride
Calcium sensing receptor (CaSR) agonist; induces osteogenic differentiation of MSCs
3300 SU 5402
Potent FGFR and VEGFR inhibitor; attenuates integrin β4-induced differentiation of neural stem cells
5383 TA 01
Induces cardiomyocyte differentiation from hESCs
5384 TA 02
Induces cardiomyocyte differentiation from hESCs
3877 TCS 2210
Inducer of neuronal differentiation in MSCs
3070 Thioridazine hydrochloride
Selective inducer of CSC differentiation; anticancer agent
3835 TWS 119
GSK-3β inhibitor; induces neuronal differentiation in ESCs
3115 WHI-P 154
JAK3 kinase inhibitor; also induces differentiation of neural progenitor cells
5148 Wnt-C59
Wnt signaling inhibitor; induces differentiation of iPSCs to cardiomyocytes
2293 Zebularine
DNA methyltransferase inhibitor; induces cardiomyocyte differentiation in MSCs
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Cancer Research Product Guide

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Stem Cell Toolbox

80 Stem Cell modulators supplied pre-dissolved in DMSO

Tocriscreen Stem Cell  Toolbox

Includes many of the latest compounds available for stem cell research. Covers compounds for stem cell differentiation, signaling and reprogramming.

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Stem Cells Review

Written by K. Clarke et al

Stem Cells Scientific Review

Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming. Request copy or view PDF today.

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