Hepatocyte Stem Cells

There are thought to be three distinct populations of hepatocyte stem cells, although how the three populations work together is not fully understood. Hepatocyte stem cells are being investigated for their regenerative medicine capabilities and for their uses in drug toxicity screening.

Literature (4)
Cat. No. Product Name / Activity
5254 FH 1
Enhances iPSC-derived hepatocyte differentiation and maturation
3850 Sodium butyrate
Directs differentiation of mESCs into hepatocytes; HDAC inhibitor

There are thought to be three distinct populations of hepatocyte stem cells, although how the three populations work together is not fully understood.

Hepatocytes themselves are reported to be stem cells in their own right. Hepatic trauma induces a rapid regenerative response to restore damaged liver cells through hepatocyte self-replication. More sever hepatic injury can activate a second population of hepatocyte stem cells, which are located within the intrahepatic biliary tree. These cells can differentiate into hepatocytes and biliary epithelial cells. The third population of hepatocyte stem cells are found in the bone marrow; these hepatocyte stem cells are reported to have the greatest impact on liver regeneration.

In vitro studies have already shown proof-of-principle for liver organogenesis from both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). As the science progresses, hepatocyte stem cells are likely to pave the way for liver transplantation, without the need of a donor. Hepatocytes are also a promising tool for drug toxicity screening of potential drug candidates.

Literature for Hepatocyte Stem Cells

Tocris offers the following scientific literature for Hepatocyte Stem Cells to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products
Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cell Workflow Poster

Stem Cell Workflow Poster

Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.