Mesenchymal Stem Cells

Mesenchymal Stem Cells (MSCs) are a heterogeneous subset of stromal stem cells that originate from the mesoderm layer of the fetus. They can differentiate into cells of the mesodermal lineage, such as adipocytes, and osteocytes.

Literature (4)

Mesenchymal Stem Cells Inhibitors

Cat. No. Product Name / Activity
7902 PIK 90
Used in hPSCs mesendoderm differentiation, also potent PI3K inhibitor


Cat. No. Product Name / Activity
2840 AICAR
AMPK activator; promotes osteogenic differentiation of bone marrow-derived MSCs
3842 5-Azacytidine
DNA methyltransferase inhibitor; induces differentiation of MSCs into cardiomyocytes
1126 Dexamethasone
Anti-inflammatory glucocorticoid; induces differentiation of human MSCs
4513 Kartogenin
Potently induces chondrogenesis in MSCs
6787 KI-7
Potentiates osteoblast differentiation from MSCs; A2B receptor positive allosteric modulator
7874 N-Acetylcysteine
Protects hMSCs against mitoptosis, necroptosis and apoptosis; also GSH precursor and antioxidant
4106 Nicotinamide
Promotes MSC differentiation; anti-inflammatory agent
5778 2-Phospho-L-ascorbic acid trisodium salt
Ascorbic acid derivative; maintains differentiation potential in bone marrow-derived MSCs
4551 Purmorphamine
Smo receptor agonist; induces differentiation of mesenchymal progenitor cells into osteoblasts
6187 SK 216
Attenuates TGF-β-dependent epithelial-mesenchymal transition; Also PAI-1 inhibitor
1496 SP 600125
JNK inhibitor; promotes differentiation of MSCs
2293 Zebularine
DNA methyltransferase inhibitor; induces cardiomyocyte differentiation in MSCs

Literature for Mesenchymal Stem Cells

Tocris offers the following scientific literature for Mesenchymal Stem Cells to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
  • Differentiation
  • Reprogramming
  • Organoid Generation
  • GMP and Ancillary Material Grade Products
Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cell Workflow Poster

Stem Cell Workflow Poster

Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.