EML 425

Pricing Availability   Qty
Description: Reversible and non-competitive CBP/p300 inhibitor
Chemical Name: 5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for EML 425

EML 425 is a reversible and non-competitive CBP/p300 inhibitor (IC50 values are 1.1 and 2.9 μM, respectively). Cell permeable.

Compound Libraries for EML 425

EML 425 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for EML 425

M. Wt 440.49
Formula C27H24N2O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1675821-32-5
PubChem ID 91826273
Smiles CC1=C(/C=C2C(N(CC3=CC=CC=C3)C(N(CC4=CC=CC=C4)C\2=O)=O)=O)C(C)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for EML 425

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 44.05 100

Preparing Stock Solutions for EML 425

The following data is based on the product molecular weight 440.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.14 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for EML 425

References are publications that support the biological activity of the product.

Milite et al (2015) A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach. J.Med.Chem. 58 2779 PMID: 25730130

If you know of a relevant reference for EML 425, please let us know.

View Related Products by Product Action

View all Histone Acetyltransferase Inhibitors

Keywords: EML 425, EML 425 supplier, EML425, CBP, CREB, proteins, histone, lysine, acetyltransferases, inhibits, inhibitors, HAT, KAT, reversible, non-competitive, Histone, Acetyltransferases, Post-translational, Modifications, 5646, Tocris Bioscience

Citations for EML 425

Citations are publications that use Tocris products.

Currently there are no citations for EML 425. Do you know of a great paper that uses EML 425 from Tocris? Please let us know.

Reviews for EML 425

There are currently no reviews for this product. Be the first to review EML 425 and earn rewards!

Have you used EML 425?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.