EML 425

Pricing Availability Delivery Time Qty
Cat.No. 5646 - EML 425 | C27H24N2O4 | CAS No. 1675821-32-5
Description: Reversible and non-competitive CBP/p300 inhibitor
Chemical Name: 5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Purity: ≥98% (HPLC)

Biological Activity

Reversible and non-competitive CBP/p300 inhibitor (IC50 values are 1.1 and 2.9 μM, respectively). Cell permeable.

Technical Data

M. Wt 440.49
Formula C27H24N2O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1675821-32-5
PubChem ID 91826273
Smiles CC1=C(/C=C2C(N(CC3=CC=CC=C3)C(N(CC4=CC=CC=C4)C\2=O)=O)=O)C(C)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 44.05 100
ethanol 8.81 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 440.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.14 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Milite et al (2015) A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach. J.Med.Chem. 58 2779 PMID: 25730130

If you know of a relevant reference for EML 425, please let us know.

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Keywords: EML425 CBP CREB proteins histone lysine acetyltransferases inhibits inhibitors HAT KAT reversible non-competitive Histone Acetyltransferases

Citations for EML 425

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