1-Hex-GlcNAlk

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Description: Metabolic chemical reporter for studying glycosylation and glycoproteins
Chemical Name: (2S,3R,4R,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(pent-4-ynamido)tetrahydro-2H-pyran-2-yl hexanoate
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for 1-Hex-GlcNAlk

1-Hex-GlcNAlk is a metabolic chemical reporter (MCR) for studying glycoproteins and glycosylation; it comprises GlcNAlk functionalized at the anomeric position with hexanoic acid. 1-Hex-GlcNAlk exhibits time- and concentration-dependent specific enzymatic labeling of proteins in HeLa cells, with negligible background labeling detected in cell lysates.

Technical Data for 1-Hex-GlcNAlk

M. Wt 357.4
Formula C17H27NO7
Storage Store at -20°C
Purity ≥95% (HPLC)
InChI Key PJQZXSANZZIQIK-YFTGLANFSA-N
Smiles OC[C@H]1O[C@@H](OC(CCCCC)=O)[C@H](NC(CCC#C)=O)[C@@H](O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 1-Hex-GlcNAlk

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.74 100

Preparing Stock Solutions for 1-Hex-GlcNAlk

The following data is based on the product molecular weight 357.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.8 mL 13.99 mL 27.98 mL
5 mM 0.56 mL 2.8 mL 5.6 mL
10 mM 0.28 mL 1.4 mL 2.8 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets for 1-Hex-GlcNAlk

References for 1-Hex-GlcNAlk

References are publications that support the biological activity of the product.

Pedowitz et al (2021) Anomeric fatty acid functionalization prevents nonenzymatic S-glycosylation by monosaccharide metabolic chemical reporters. ACS Chem Biol 16 1924 PMID: 34282887


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Keywords: 1-Hex-GlcNAlk, 1-Hex-GlcNAlk supplier, glycosylation, glycoproteins, probes, bio-orthogonal, labeling, labelling, metabolic, chemical, reporter, MCR, Glycobiology, Probes, Post-translational, Modifications, 7751, Tocris Bioscience

Citations for 1-Hex-GlcNAlk

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