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Description: Metabolic chemical reporter for studying glycosylation and glycoproteins
Chemical Name: 2-Deoxy-2-[(1-oxo-4-pentyn-1-yl)amino]-D-galactopyranose-1,3,4,6-tetraacetate
Purity: ≥95% (HPLC)

Biological Activity for Ac4GalNAlk

Ac4GalNAlk is a metabolic chemical reporter (MCR) for studying glycosylation and glycoproteins. In cells expressing the engineered pyrophosphorylase mut-AGX1, Ac4GalNAlk is efficiently converted into UDP- Ac4GalNAlk which is incorporated into Ac4GalNAlk-containing glycoproteins.

Technical Data for Ac4GalNAlk

M. Wt 427.41
Formula C19H25NO10
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1810852-60-8
Smiles CC(O[C@@H]1[C@H](C(O[C@@H]([C@@H]1OC(C)=O)COC(C)=O)OC(C)=O)NC(CCC#C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ac4GalNAlk

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.74 100

Preparing Stock Solutions for Ac4GalNAlk

The following data is based on the product molecular weight 427.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.34 mL 11.7 mL 23.4 mL
5 mM 0.47 mL 2.34 mL 4.68 mL
10 mM 0.23 mL 1.17 mL 2.34 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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References for Ac4GalNAlk

References are publications that support the biological activity of the product.

Cioce et al (2021) Optimization of metabolic oligosaccharide engineering with Ac4GalNAlk and Ac4GlcNAlk by an engineered pyrophosphorylase. ACS Chem.Biol. 16 1961 PMID: 33835779

If you know of a relevant reference for Ac4GalNAlk, please let us know.

Keywords: Ac4GalNAlk, Ac4GalNAlk supplier, glycosylation, glycoproteins, probe, probes, UDP-, Ac4GalNAlk, labeling, labelling, metabolic, chemical, reporter, MCR, Glycobiology, Probes, Post-translational, Modifications, Biochemicals, and, Molecular, Biology, 8035, Tocris Bioscience

Citations for Ac4GalNAlk

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