NU 9056

Pricing Availability   Qty
Description: Inhibitor of KAT5 (Tip60)
Chemical Name: 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole
Citations (6)
Literature (3)

Biological Activity for NU 9056

NU 9056 is a selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.

Technical Data for NU 9056

M. Wt 232.37
Formula C6H4N2S4
Storage Store at -20°C
CAS Number 1450644-28-6
PubChem ID 72201043
Smiles C1(SSC2=CC=NS2)=CC=NS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NU 9056

Solubility Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)

Product Datasheets for NU 9056

Certificate of Analysis / Product Datasheet
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References for NU 9056

References are publications that support the biological activity of the product.

Coffey et al (2012) Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One 7 e45539 PMID: 23056207

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View all Histone Acetyltransferase Inhibitors

Keywords: NU 9056, NU 9056 supplier, NU9056, KAT5, Tip60, histone, acetyltransferase, HAT, inhibitors, inhibits, acetylation, dna, damage, proliferation, apoptosis, caspase, Histone, Acetyltransferases, Post-translational, Modifications, 4903, Tocris Bioscience

6 Citations for NU 9056

Citations are publications that use Tocris products. Selected citations for NU 9056 include:

Bakshi et al (2017) Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion. Sci Rep 7 3635 PMID: 28623334

Rollins et al (2017) Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae. PLoS Genet 13 e1006626 PMID: 28231279

Parira et al (2017) Novel detection of post-translational modifications in human monocyte-derived dendritic cells after chronic alcohol exposure: Role of inflammation regulator H4K12ac. Sci Rep 7 11236 PMID: 28894190

Scaglione et al (2018) PRMT5-mediated regulation of developmental myelination. Nat Commun 9 2840 PMID: 30026560

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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