NU 9056

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Cat.No. 4903 - NU 9056 | C6H4N2S4 | CAS No. 1450644-28-6
Description: Inhibitor of KAT5 (Tip60)
Chemical Name: 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole
Citations (3)

Biological Activity

Selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.

Technical Data

M. Wt 232.37
Formula C6H4N2S4
Storage Store at -20°C
CAS Number 1450644-28-6
PubChem ID 72201043
Smiles C1(SSC2=CC=NS2)=CC=NS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 232.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.3 mL 21.52 mL 43.03 mL
5 mM 0.86 mL 4.3 mL 8.61 mL
10 mM 0.43 mL 2.15 mL 4.3 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Coffey et al (2012) Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One 7 e45539 PMID: 23056207

If you know of a relevant reference for NU 9056, please let us know.

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View all Histone Acetyltransferase Inhibitors

Keywords: NU 9056, supplier, NU9056, KAT5, Tip60, histone, acetyltransferase, HAT, inhibitors, inhibits, acetylation, dna, damage, proliferation, apoptosis, caspase, Histone, Acetyltransferases, Post-translational, Modifications, Histone, Acetyltransferases, Tocris Bioscience

3 Citations for NU 9056

Citations are publications that use Tocris products. Selected citations for NU 9056 include:

Bakshi et al (2017) Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion. Sci Rep 7 3635 PMID: 28623334

Rollins et al (2017) Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae. PLoS Genet 13 e1006626 PMID: 28231279

Parira et al (2017) Novel detection of post-translational modifications in human monocyte-derived dendritic cells after chronic alcohol exposure: Role of inflammation regulator H4K12ac. Sci Rep 7 11236 PMID: 28894190

Do you know of a great paper that uses NU 9056 from Tocris? If so please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer Research Product Guide

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Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.


Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

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