NU 9056

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Cat.No. 4903 - NU 9056 | C6H4N2S4 | CAS No. 1450644-28-6
Description: Inhibitor of KAT5 (Tip60)
Chemical Name: 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.

Technical Data

M. Wt 232.37
Formula C6H4N2S4
Storage Store at -20°C
CAS Number 1450644-28-6
PubChem ID 72201043
InChI Key MLRAMCAHIWHWRM-UHFFFAOYSA-N
Smiles C1(SSC2=CC=NS2)=CC=NS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Coffey et al (2012) Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One 7 e45539 PMID: 23056207


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View all Histone Acetyltransferase Inhibitors

Keywords: NU 9056, NU 9056 supplier, NU9056, KAT5, Tip60, histone, acetyltransferase, HAT, inhibitors, inhibits, acetylation, dna, damage, proliferation, apoptosis, caspase, Histone, Acetyltransferases, Post-translational, Modifications, 4903, Tocris Bioscience

3 Citations for NU 9056

Citations are publications that use Tocris products. Selected citations for NU 9056 include:

Bakshi et al (2017) Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion. Sci Rep 7 3635 PMID: 28623334

Rollins et al (2017) Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae. PLoS Genet 13 e1006626 PMID: 28231279

Parira et al (2017) Novel detection of post-translational modifications in human monocyte-derived dendritic cells after chronic alcohol exposure: Role of inflammation regulator H4K12ac. Sci Rep 7 11236 PMID: 28894190


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases