Selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)|
Preparing Stock Solutions
The following data is based on the product molecular weight 232.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.3 mL||21.52 mL||43.03 mL|
|5 mM||0.86 mL||4.3 mL||8.61 mL|
|10 mM||0.43 mL||2.15 mL||4.3 mL|
|50 mM||0.09 mL||0.43 mL||0.86 mL|
References are publications that support the products' biological activity.
Coffey et al (2012) Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One 7 e45539 PMID: 23056207
If you know of a relevant reference for NU 9056, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: NU 9056, supplier, NU9056, KAT5, Tip60, histone, acetyltransferase, HAT, inhibitors, inhibits, acetylation, dna, damage, proliferation, apoptosis, caspase, Histone, Acetyltransferases, Post-translational, Modifications, Histone, Acetyltransferases, Tocris Bioscience
Citations for NU 9056
Citations are publications that use Tocris products.
Currently there are no citations for NU 9056. Do you know of a great paper that uses NU 9056 from Tocris? If so please let us know.
Reviews for NU 9056
There are currently no reviews for this product. Be the first to review NU 9056 and earn rewards!
Have you used NU 9056?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics Research Bulletin
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases